Suppr超能文献

开发抗新冠病毒进化的药物。

Developing evolution-resistant drugs for COVID-19.

机构信息

Department of Ecology, Evolution and Organismal Biology, Brown University, Providence, United States.

Center for Computational Molecular Biology, Brown University, Providence, United States.

出版信息

Elife. 2022 Jul 26;11:e81334. doi: 10.7554/eLife.81334.

Abstract

Analyzing how mutations affect the main protease of SARS-CoV-2 may help researchers develop drugs that are effective against current and future variants of the virus.

摘要

分析突变如何影响 SARS-CoV-2 的主蛋白酶,可能有助于研究人员开发出针对当前和未来病毒变体有效的药物。

相似文献

1
Developing evolution-resistant drugs for COVID-19.
Elife. 2022 Jul 26;11:e81334. doi: 10.7554/eLife.81334.
2
In silico evaluation of Philippine Natural Products against SARS-CoV-2 Main Protease.
J Mol Model. 2022 Oct 7;28(11):345. doi: 10.1007/s00894-022-05334-1.
3
Potent inhibitors of SARS-CoV-2 3C-like protease derived from N-substituted isatin compounds.
Eur J Med Chem. 2020 Nov 15;206:112702. doi: 10.1016/j.ejmech.2020.112702. Epub 2020 Aug 1.
4
Virtual screening and repurposing of FDA approved drugs against COVID-19 main protease.
Life Sci. 2020 Jun 15;251:117627. doi: 10.1016/j.lfs.2020.117627. Epub 2020 Apr 3.
8
AI-Aided Design of Novel Targeted Covalent Inhibitors against SARS-CoV-2.
Biomolecules. 2022 May 25;12(6):746. doi: 10.3390/biom12060746.
10
Progress of SARS-CoV-2 Main protease peptide-like inhibitors.
Chem Biol Drug Des. 2024 Jan;103(1):e14425. doi: 10.1111/cbdd.14425. Epub 2023 Dec 11.

引用本文的文献

1
3-chymotrypsin-like protease in SARS-CoV-2.
Biosci Rep. 2024 Aug 28;44(8). doi: 10.1042/BSR20231395.
2
Antiviral treatment of COVID-19 is associated with lack of immune response.
J Med Virol. 2023 Jan;95(1):e28233. doi: 10.1002/jmv.28233. Epub 2022 Oct 24.

本文引用的文献

1
Bad news for Paxlovid? Resistance may be coming.
Science. 2022 Jul 8;377(6602):138-139. doi: 10.1126/science.add8037. Epub 2022 Jul 7.
2
Defining the substrate envelope of SARS-CoV-2 main protease to predict and avoid drug resistance.
Nat Commun. 2022 Jun 21;13(1):3556. doi: 10.1038/s41467-022-31210-w.
4
New subvariants are masters of immune evasion.
Science. 2022 May 13;376(6594):679-680. doi: 10.1126/science.adc9448. Epub 2022 May 12.
5
Identification of SARS-CoV-2 inhibitors targeting Mpro and PLpro using in-cell-protease assay.
Commun Biol. 2022 Feb 25;5(1):169. doi: 10.1038/s42003-022-03090-9.
6
Beyond Omicron: what's next for COVID's viral evolution.
Nature. 2021 Dec;600(7888):204-207. doi: 10.1038/d41586-021-03619-8.
7
An oral SARS-CoV-2 M inhibitor clinical candidate for the treatment of COVID-19.
Science. 2021 Dec 24;374(6575):1586-1593. doi: 10.1126/science.abl4784. Epub 2021 Nov 2.
8
Dynamic Profiling of β-Coronavirus 3CL M Protease Ligand-Binding Sites.
J Chem Inf Model. 2021 Jun 28;61(6):3058-3073. doi: 10.1021/acs.jcim.1c00449. Epub 2021 Jun 14.
9
Structure of M from SARS-CoV-2 and discovery of its inhibitors.
Nature. 2020 Jun;582(7811):289-293. doi: 10.1038/s41586-020-2223-y. Epub 2020 Apr 9.
10
A new coronavirus associated with human respiratory disease in China.
Nature. 2020 Mar;579(7798):265-269. doi: 10.1038/s41586-020-2008-3. Epub 2020 Feb 3.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验