Batton D G, Nardis E E
Pediatr Res. 1987 May;21(5):511-5. doi: 10.1203/00006450-198705000-00018.
We investigated the effect of intraventricular blood on cerebral blood flow in the newborn puppy by infusing autologous blood into the lateral ventricle to produce and maintain an intraventricular pressure of approximately 15 mm Hg (mild insult), 30 mm Hg (moderate insult), or 50 mm Hg (severe insult) for 20 min. As the intraventricular pressure increased, flow decreased progressively to all areas of the brain directly proportional to the cerebral perfusion pressure. On return of the intraventricular pressure to baseline level, cerebral blood flow normalized despite the continued presence of a large amount of blood within the lateral ventricles. We suggest that blood within the ventricular system can result in a significant acute reduction of cerebral blood flow which appears to be mediated through the effect on cerebral perfusion pressure.
我们通过向新生幼犬的侧脑室注入自体血，使其产生并维持约15毫米汞柱（轻度损伤）、30毫米汞柱（中度损伤）或50毫米汞柱（重度损伤）的脑室内压20分钟，研究了脑室内血液对其脑血流的影响。随着脑室内压升高，流向脑各个区域的血流逐渐减少，与脑灌注压成正比。当脑室内压恢复到基线水平时，尽管侧脑室内仍有大量血液，但脑血流恢复正常。我们认为，脑室系统内的血液可导致脑血流显著急性减少，这似乎是通过对脑灌注压的影响介导的。
