The Departments of Cerebrovascular Diseases; Henan Medical Key Laboratory of Translational Cerebrovascular Diseases, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Hotchkiss Brain Institute and Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada.
Stroke Vasc Neurol. 2020 Dec;5(4):388-395. doi: 10.1136/svn-2020-000334. Epub 2020 Mar 26.
Spontaneous intracerebral haemorrhage (ICH) is a devastating type of stroke with high mortality and morbidity and for which no effective treatments are available to date. Much experimental and clinical research have been performed to explore its mechanisms regard the subsequent inflammatory cascade and to seek the potential therapeutic strategies. The aim of this review is to discuss insights from clinical settings that have led to the development of numerous animal models of ICH. Some of the current and future challenges for clinicians to understand ICH are also surveyed.
自发性脑出血（ICH）是一种具有高死亡率和发病率的破坏性中风类型，迄今为止尚无有效的治疗方法。为了探索其后续炎症级联反应的机制并寻求潜在的治疗策略，已经进行了大量的实验和临床研究。本文的目的是讨论从临床角度得出的一些见解，这些见解导致了许多 ICH 动物模型的发展。还调查了目前和未来临床医生在理解 ICH 方面面临的一些挑战。
