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飞秒激光诱导 Ti6Al4V 及其块体非晶合金表面微纳结构的生物相容性。

Biocompatibility of micro/nano structures on the surface of Ti6Al4V and Ti-based bulk metallic glasses induced by femtosecond laser.

机构信息

School of Materials Engineering, Shanghai University of Engineering Science, Shanghai 201620, China; Shanghai Collaborative Innovation Center of Laser of Manufacturing Technology, Shanghai 201620, China.

School of Materials Engineering, Shanghai University of Engineering Science, Shanghai 201620, China; Shanghai Collaborative Innovation Center of Laser of Manufacturing Technology, Shanghai 201620, China; Fraunhofer Institute for Laser Technology ILT, Aachen 52074, Germany.

出版信息

Biomater Adv. 2022 Aug;139:212998. doi: 10.1016/j.bioadv.2022.212998. Epub 2022 Jun 25.

DOI:10.1016/j.bioadv.2022.212998
PMID:35882146
Abstract

Femtosecond laser surface modification has been proved to be a versatile technology to create various functional materials by modifying solid surface properties. An interesting experimental phenomenon is found by exposing a Ti6Al4V alloy and Ti-based metallic glass to femtosecond laser irradiation. The research results show that the femtosecond laser induces different micro-nano structures on the surfaces of Ti6Al4V alloy and Ti-based metallic glass. Spherical structure and LIPSS (Laser-induced periodic surface structures) can be formed on the surface of Ti6Al4V alloy after femtosecond laser irradiation. On the surface of Ti-based metallic glass, LIPSS, SWPSS (Super-wavelength periodic surface structure) and neatly arranged microholes structures can be found. Under the same laser parameters, the micro-nano structures showed different evolution trends on the Ti6Al4V alloy and Ti-based metallic glass surfaces. The difference in surface structure between Ti6Al4V alloy and Ti-based metallic glass is since amorphous materials have no crystal lattice and a fixed melting temperature. In addition, there are differences in the biocompatibility of different surface structures. The size and distance of the micro-pits on the surface of different structures determine the ability of cells to adhesion, proliferate and differentiate. This conclusion has important significance for the application of Ti6Al4V alloy and Ti-based metallic glass in the field of biomedicine.

摘要

飞秒激光表面改性被证明是一种通过改变固体表面性能来制造各种功能材料的通用技术。通过对 Ti6Al4V 合金和 Ti 基金属玻璃进行飞秒激光辐照,发现了一个有趣的实验现象。研究结果表明,飞秒激光在 Ti6Al4V 合金和 Ti 基金属玻璃表面诱导不同的微纳结构。在飞秒激光辐照后,Ti6Al4V 合金表面可以形成球形结构和 LIPSS(激光诱导周期表面结构)。在 Ti 基金属玻璃表面,可以发现 LIPSS、SWPSS(超波长周期表面结构)和排列整齐的微孔结构。在相同的激光参数下,微纳结构在 Ti6Al4V 合金和 Ti 基金属玻璃表面表现出不同的演化趋势。Ti6Al4V 合金和 Ti 基金属玻璃表面结构的差异是由于非晶材料没有晶格和固定的熔化温度。此外,不同表面结构的生物相容性也存在差异。不同结构表面微坑的大小和间距决定了细胞黏附、增殖和分化的能力。这一结论对 Ti6Al4V 合金和 Ti 基金属玻璃在生物医学领域的应用具有重要意义。

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