Institute of Plant and Environmental Sciences, Faculty of Agrobiology and Food Resources, Slovak University of Agriculture in Nitra, Tr. A. Hlinku 2, 94976 Nitra, Slovakia.
Cells. 2022 Jul 8;11(14):2151. doi: 10.3390/cells11142151.
Lignans, as secondary metabolites synthesized within a phenylpropanoid pathway, play various roles in plants, including their involvement in growth and plant defense processes. The health and nutritional benefits of lignans are unquestionable, and many studies have been devoted to these attributes. Although the regulatory role of miRNAs in the biosynthesis of secondary metabolites has been widely reported, there is no systematic review available on the miRNA-based regulatory mechanism of lignans biosynthesis. However, the genetic background of lignan biosynthesis in plants is well characterized. We attempted to put together a regulatory mosaic based on current knowledge describing miRNA-mediated regulation of genes, enzymes, or transcription factors involved in this biosynthesis process. At the same time, we would like to underline the fact that further research is necessary to improve our understanding of the miRNAs regulating plant lignan biosynthesis by exploitation of current approaches for functional identification of miRNAs.
木脂素作为苯丙烷途径合成的次生代谢物，在植物中发挥着多种作用，包括参与生长和植物防御过程。木脂素具有健康和营养方面的益处，这一点毋庸置疑，许多研究都致力于探讨其相关属性。尽管 miRNA 在次生代谢物生物合成中的调控作用已被广泛报道，但目前尚无关于 miRNA 调控木脂素生物合成的系统综述。然而，植物中木脂素生物合成的遗传背景已经得到很好的描述。我们试图根据目前描述 miRNA 介导的参与该生物合成过程的基因、酶或转录因子调控的知识，构建一个调控模块。同时，我们还想强调，需要进一步研究，通过利用当前鉴定 miRNA 功能的方法，来改善我们对调节植物木脂素生物合成的 miRNA 的理解。
