Yin Hui, Chen Jiemin, Chen Qiuyue, Lyu Guorong
Department of Ultrasonography, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China.
Sci Rep. 2024 Dec 28;14(1):30799. doi: 10.1038/s41598-024-81033-6.
We evaluated the impact of adenomyosis and ovarian endometriosis on ovarian reserve function through transvaginal three-dimensional ultrasound and anti-mullerian hormone testing. A total of 150 female patients who were admitted to our hospital from January 2023 to May 2024 were selected; 58 cases had adenomyosis (adenomyosis group), 36 had ovarian endometriosis (ovarian endometriosis group), and 56 were healthy (healthy group). There were no statistically significant differences in clinical baseline data among the three groups (all P > 0.05). However, significant overall differences were found in anti-Mullerian hormone levels, antral follicle count, ovarian volume, vascularization index, flow index, and vascularization flow index among the three groups (F values were 90.34, 146.50, 92.61, 63.87, 59.50, 49.36 respectively; all P < 0.001); compared to the healthy group, these indicators were all decreased in the adenomyosis group and ovarian endometriosis group (all P < 0.05). Pearson correlation analysis revealed that serum anti-mullerian hormone levels were positively correlated with antral follicle count, ovarian volume, vascularization index, flow index, and vascularization flow index (r = 0.80, 0.73, 0.50, 0.48, 0.45, respectively; all P < 0.01). These data suggest that adenomyosis and ovarian endometriosis can lead to a decline in ovarian reserve function in women of reproductive age compared to their peers. Also, antral follicle count and ovarian volume are the optimal indicators for evaluating ovarian reserve function in these patients.
我们通过经阴道三维超声和抗苗勒管激素检测，评估了子宫腺肌病和卵巢子宫内膜异位症对卵巢储备功能的影响。选取了2023年1月至2024年5月期间我院收治的150例女性患者；58例患有子宫腺肌病（子宫腺肌病组），36例患有卵巢子宫内膜异位症（卵巢子宫内膜异位症组），56例为健康女性（健康组）。三组患者的临床基线数据无统计学显著差异（均P>0.05）。然而，三组患者的抗苗勒管激素水平、窦卵泡计数、卵巢体积、血管化指数、血流指数和血管化血流指数存在显著的总体差异（F值分别为90.34、146.50、92.61、63.87、59.50、49.36；均P<0.001）；与健康组相比，子宫腺肌病组和卵巢子宫内膜异位症组的这些指标均降低（均P<0.05）。Pearson相关性分析显示，血清抗苗勒管激素水平与窦卵泡计数、卵巢体积、血管化指数、血流指数和血管化血流指数呈正相关（r分别为0.80、0.73、0.50、0.48、0.45；均P<0.01）。这些数据表明，与同龄人相比，子宫腺肌病和卵巢子宫内膜异位症可导致育龄期女性卵巢储备功能下降。此外，窦卵泡计数和卵巢体积是评估这些患者卵巢储备功能的最佳指标。
