Leodolter S, Müller-Tyl E, Philipp K, Salem G, Janisch H
Z Geburtshilfe Perinatol. 1979 Apr;183(2):111-7.
The administration of betamimetics has proved to be useful for symptom-oriented treatment in patients with reduced utero-placental flow. In order to quantify the betamimetic effect flow measurements were carried out in a total of 12 sheep, yielding the following experimental results: 1) Betamimetics, up to a certain point which correlates with maternal heart rate, raise the uteroplacental flow-rate. 2) The use of cardio-selective betablocker prevents undesired betamimetic side-effects but there is also a loss of the rise in utero-placental flow rate. 3) In sheep pretreated with Oxytoxin the application of betamimetics not only offsets oxytoxin-action but also greatly improves utero-placental blood flow.
已证明，β-拟交感神经药对子宫胎盘血流减少的患者进行以症状为导向的治疗是有用的。为了量化β-拟交感神经药的作用，对总共12只绵羊进行了血流测量，得出以下实验结果：1）在与母体心率相关的某个点之前，β-拟交感神经药可提高子宫胎盘血流速度。2）使用心脏选择性β受体阻滞剂可防止不想要的β-拟交感神经药副作用，但子宫胎盘血流速度的升高也会丧失。3）在用催产素预处理的绵羊中，应用β-拟交感神经药不仅可抵消催产素的作用，还可大大改善子宫胎盘血流。
