Khambati Alisha, Wright Robert Emery, Das Susmita, Pasula Shirisha, Sepulveda Alejandro, Hernandez Francis, Kanwar Mamta, Chandrasekar Pranatharthi, Kumar Ashok
Department of Ophthalmology, Visual and Anatomical Sciences, School of Medicine, Wayne State University, Detroit, MI 48201, USA.
Division of Infectious Diseases, Department of Internal Medicine, School of Medicine, Wayne State University, Detroit, MI 48201, USA.
J Fungi (Basel). 2022 Jun 22;8(7):656. doi: 10.3390/jof8070656.
Fungal endophthalmitis is one of the leading causes of vision loss worldwide. Post-operative and traumatic injuries are major contributing factors resulting in ocular fungal infections in healthy and, more importantly, immunocompromised individuals. Among the fungal pathogens, the species, , continues to be more prevalent in fungal endophthalmitis patients. However, due to overlapping clinical symptoms with other endophthalmitis etiology, fungal endophthalmitis pose a challenge in its diagnosis and treatment. Hence, it is critical to understand its pathobiology to develop and deploy proper therapeutic interventions for combating infections. This review highlights the different modes of transmission and the host immune response during endophthalmitis. Additionally, we discuss recent advancements in the diagnosis of fungal endophthalmitis. Finally, we comprehensively summarize various antifungal regimens and surgical options for the treatment of endophthalmitis.
真菌性眼内炎是全球视力丧失的主要原因之一。术后和外伤是导致健康人群，更重要的是免疫功能低下人群发生眼部真菌感染的主要因素。在真菌病原体中， 种在真菌性眼内炎患者中仍然更为普遍。然而，由于与其他眼内炎病因的临床症状重叠，真菌性眼内炎在其诊断和治疗方面构成挑战。因此，了解其病理生物学对于开发和部署对抗 感染的适当治疗干预措施至关重要。本综述重点介绍了眼内炎期间 的不同传播模式和宿主免疫反应。此外，我们讨论了真菌性眼内炎诊断的最新进展。最后，我们全面总结了治疗 眼内炎的各种抗真菌方案和手术选择。
