原发性和继发性线粒体疾病：病因及治疗策略
Primary and Secondary Mitochondrial Diseases: Etiologies and Therapeutic Strategies.
作者信息
Valenti Daniela, Vacca Rosa Anna
机构信息
Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies (IBIOM), National Research Council (CNR), Via G. Amendola122/O, 70126 Bari, Italy.
出版信息
J Clin Med. 2022 Jul 20;11(14):4209. doi: 10.3390/jcm11144209.
Abstract
Mitochondria are complex and multifaceted organelles that constitute a dynamic network of signaling platforms playing a pivotal role in cellular energy-generating processes [...].
摘要
线粒体是复杂且多面的细胞器，构成了一个动态的信号平台网络，在细胞能量产生过程中发挥着关键作用[……]
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本文引用的文献
1
Mitochondrial disease in children.儿童线粒体疾病。
J Intern Med. 2020 Jun;287(6):609-633. doi: 10.1111/joim.13054. Epub 2020 Apr 7.
2
Mitochondrial medicine in the omics era.组学时代的线粒体医学。
Lancet. 2018 Jun 23;391(10139):2560-2574. doi: 10.1016/S0140-6736(18)30727-X. Epub 2018 Jun 18.
3
Mitochondrial diseases.线粒体疾病。
Nat Rev Dis Primers. 2016 Oct 20;2:16080. doi: 10.1038/nrdp.2016.80.
4
Primary Mitochondrial Disease and Secondary Mitochondrial Dysfunction: Importance of Distinction for Diagnosis and Treatment.原发性线粒体疾病与继发性线粒体功能障碍：鉴别诊断与治疗的重要性。
Mol Syndromol. 2016 Jul;7(3):122-37. doi: 10.1159/000446586. Epub 2016 Jun 3.
5
Mitochondrial disease in childhood: mtDNA encoded.儿童线粒体疾病：mtDNA 编码。
Neurotherapeutics. 2013 Apr;10(2):199-211. doi: 10.1007/s13311-012-0167-0.
6
Inherited mitochondrial disorders.遗传性线粒体疾病。
Adv Exp Med Biol. 2012;942:187-213. doi: 10.1007/978-94-007-2869-1_8.
7
DNA repair in organelles: Pathways, organization, regulation, relevance in disease and aging.细胞器中的DNA修复：途径、组织、调控、在疾病与衰老中的相关性
Biochim Biophys Acta. 2011 Jan;1813(1):186-200. doi: 10.1016/j.bbamcr.2010.10.002. Epub 2010 Oct 13.
8
A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine.代谢性疾病、退行性疾病、衰老及癌症的线粒体范式：进化医学的曙光。
Annu Rev Genet. 2005;39:359-407. doi: 10.1146/annurev.genet.39.110304.095751.
9
Mitochondrial cytopathies.线粒体细胞病
J Neurol. 2003 Mar;250(3):267-77. doi: 10.1007/s00415-003-0978-3.
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