Kang Min-Seung, Moon Kyung-Jin, Lee Ji-Eun, Jeong Young-Il
Department of Ophthalmology, Pusan National University Yangsan Hospital, Yangsan 50612, Gyeongnam, Korea.
School of Medicine, Pusan National University, Yangsan 50612, Gyeongnam, Korea.
Materials (Basel). 2022 Jul 11;15(14):4823. doi: 10.3390/ma15144823.
The aim of this study is to prepare ciprofloxacin (CIP) or levofloxacin (LEVO)-incorporated and polydopamine (PDA)-coated nephrite composites for application in drug-eluting contact lenses. PDA was coated onto the surface of nephrite to improve antibacterial activity and to payload antibiotics. CIP or LEVO was incorporated into the PDA layer on the surface of nephrite. Furthermore, CIP-incorporated/PDA-coated nephrite composites were embedded into the contact lenses. PDA-coated nephrite composites showed dull and smooth surfaces according to the dopamine concentration while nephrite itself has sharp surface morphology. CIP- or LEVO-loaded/PDA-coated nephrite composites also have dull and smooth surface properties. Nano and/or sub-micron clusters were observed in field emission-scanning electron microscopy (FE-SEM) observation, indicating that PDA nanoparticles were accumulated and coated onto the surface of nephrite. Furthermore, CIP- or LEVO-incorporated/PDA-coated nephrite composites showed the sustained release of CIP or LEVO in vitro and these properties contributed to the enhanced antibacterial activity of composites compared to nephrite or PDA-coated nephrite composites. CIP-incorporated/PDA-coated nephrite composites were embedded in the contact lenses and then, in an antibacterial study, they showed higher bactericidal effect against () compared to nephrite itself or PDA-coated nephrite composites. We suggest that CIP- or LEVO-loaded/PDA-coated nephrite composite-embedded contact lenses are a promising candidate for therapeutic application.
本研究的目的是制备用于药物洗脱隐形眼镜的载有环丙沙星（CIP）或左氧氟沙星（LEVO）并涂覆有聚多巴胺（PDA）的软玉复合材料。将PDA涂覆在软玉表面以提高抗菌活性并负载抗生素。将CIP或LEVO掺入软玉表面的PDA层中。此外，将载有CIP的/涂覆有PDA的软玉复合材料嵌入隐形眼镜中。根据多巴胺浓度，涂覆有PDA的软玉复合材料表面 dull 且光滑，而软玉本身具有尖锐的表面形态。负载CIP或LEVO的/涂覆有PDA的软玉复合材料也具有 dull 且光滑的表面性质。在场发射扫描电子显微镜（FE-SEM）观察中观察到纳米和/或亚微米团簇，表明PDA纳米颗粒积累并涂覆在软玉表面。此外，载有CIP或LEVO的/涂覆有PDA的软玉复合材料在体外显示出CIP或LEVO的持续释放，并且这些性质导致复合材料与软玉或涂覆有PDA的软玉复合材料相比具有增强的抗菌活性。将载有CIP的/涂覆有PDA的软玉复合材料嵌入隐形眼镜中，然后，在抗菌研究中，与软玉本身或涂覆有PDA的软玉复合材料相比，它们对（）显示出更高的杀菌效果。我们认为，负载CIP或LEVO的/涂覆有PDA的软玉复合嵌入隐形眼镜是一种有前途的治疗应用候选物。
原文中“dull”未准确翻译，因不清楚其在语境中的准确含义，暂保留英文。
