沙特阿拉伯西部地区献血者中输血传播感染与 ABO 和 Rh 血型的流行情况及相关性：一项 7 年回顾性分析。
Prevalence and Association of Transfusion Transmitted Infections with ABO and Rh Blood Groups among Blood Donors in the Western Region of Saudi Arabia: A 7-Year Retrospective Analysis.
机构信息
Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk 71491, Saudi Arabia.
Laboratory Medicine Department, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah 21955, Saudi Arabia.
出版信息
Medicina (Kaunas). 2022 Jun 27;58(7):857. doi: 10.3390/medicina58070857.
This study was aimed at determining the prevalence estimate and association of transfusion-transmitted infections (TTIs) with ABO and Rh blood groups among blood donors at the King Faisal Specialist Hospital and Research Center (KFSH & RC) in the western region of Saudi Arabia. A retrospective study was conducted at the blood bank center of KFSH and RC from 1 January 2013 to 31 December 2019. Data on ABO and Rh blood group testing, serological testing, molecular investigations, serological assays, nucleic acid testing (NATs), and socio-demographic information were gathered. During the study period, there were 959,431 blood donors at the KFSH and RC. The overall 7-year cumulative prevalence estimate of blood transfusion-transmitted infections among blood donors was low at 7.93%, with an average prevalence estimate of 0.66%. Donors with the O blood group, the O RhD +ve blood group, in particular, were more at risk of developing TTIs, whereas donors with the AB blood group, the AB RhD -ve blood group, in particular, were at the lowest risk of developing TTIs. In total, 96.9% of the blood donors were males ( = 916,567). Almost half of the blood donors belong to the O blood group (49.4%). A total of 861,279 (91.0%) donors were found to be RhD positive. The percentages of TTIs were found to be higher in RhD +ve donors compared with RhD -ve donors. The prevalence estimate of the hemoglobin C (HbC) infection was the most common TTI among the blood donors being 3.97%, followed by malaria being 2.21%. The least prevalence estimate of TTI in the present study was for NAT HIV being 0.02%. Significant associations were observed between RhD +ve and RhD -ve among the malaria-infected donors (A: χ = 26.618, = 0.001; AB: χ = 23.540, = 0.001; B: χ = 5.419, = 0.020; O: χ = 68.701, = 0.001). The current 7-year retrospective study showed a low level of TTIs among blood donors. However, we urge that more research encompassing the entire country be conducted in order to obtain more representative results in terms of the prevalence estimate and association of transfusion-transmitted infections with ABO and Rh blood groups in communities.
本研究旨在确定沙特阿拉伯西部地区的法伊萨尔国王专科医院和研究中心（KFSH & RC）献血者中输血传播感染（TTIs）的流行率估计值和与 ABO 和 Rh 血型的关联。 对 2013 年 1 月 1 日至 2019 年 12 月 31 日期间 KFSH 和 RC 血液中心的 ABO 和 Rh 血型检测、血清学检测、分子研究、血清学检测、核酸检测（NAT）和社会人口统计学信息进行了回顾性研究。 在研究期间，KFSH 和 RC 有 959,431 名献血者。 献血者中输血传播感染的 7 年累计流行率估计值较低，为 7.93%，平均流行率估计值为 0.66%。 O 血型、特别是 O RhD +ve 血型的献血者发生 TTIs 的风险更高，而 AB 血型、特别是 AB RhD -ve 血型的献血者发生 TTIs 的风险最低。 总共，96.9%的献血者为男性（=916,567）。 近一半的献血者为 O 血型（49.4%）。 总共发现 861,279 名（91.0%）献血者 RhD 阳性。 RhD +ve 供者的 TTIs 百分比高于 RhD -ve 供者。 在本研究中，血红蛋白 C（HbC）感染的流行率估计值是献血者中最常见的 TTI，为 3.97%，其次是疟疾，为 2.21%。 本研究中 TTI 的最低流行率估计值是 NAT HIV，为 0.02%。 在疟疾感染供者中观察到 RhD +ve 和 RhD -ve 之间存在显著关联（A：χ=26.618，=0.001；AB：χ=23.540，=0.001；B：χ=5.419，=0.020；O：χ=68.701，=0.001）。 当前的 7 年回顾性研究表明，献血者中的 TTIs 水平较低。 然而，我们敦促开展更多涵盖全国范围的研究，以便在社区中获得更具代表性的输血传播感染与 ABO 和 Rh 血型关联的流行率估计值。
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