放射性食管癌症：发病机制、治疗和预后的研究。
Radiation-Induced Esophageal Cancer: Investigating the Pathogenesis, Management, and Prognosis.
机构信息
First Department of Surgery, Laikon General Hospital, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Department of Radiotherapy, School of Medicine, University of Crete, 71110 Heraklion, Greece.
出版信息
Medicina (Kaunas). 2022 Jul 18;58(7):949. doi: 10.3390/medicina58070949.
One of the most serious late side effects of irradiation is the promotion of tumorigenesis. Radiation-induced esophageal cancer (RIEC) can arise in a previously irradiated field, mostly in patients previously irradiated for thoracic malignancies such as breast cancer, Hodgkin and non-Hodgkin lymphomas, head and neck cancers, lung cancer, or previous esophageal cancer. RIEC is rare and accounts for less than 1% of all carcinomas of the esophagus. There are little data available in the current literature regarding pathogenesis, diagnosis, treatment, and outcome of esophageal cancer developed in a previously irradiated field. RIEC seems to represent a biologically aggressive disease with a poor prognosis. Although it is difficult to perform radical surgery on a previously irradiated field, R0 resection remains the mainstay of treatment. The use of neoadjuvant and adjuvant chemoradiotherapy remains very helpful in RIEC, similarly to conventional esophageal cancer protocols. The aim of this article is to elucidate this rare but challenging entity.
其中最严重的晚期放射性副作用之一是促进肿瘤发生。放射性诱导的食管癌（RIEC）可发生于先前照射过的区域，主要见于先前因胸部恶性肿瘤（如乳腺癌、霍奇金和非霍奇金淋巴瘤、头颈部癌、肺癌或先前的食管癌）而接受过放疗的患者。RIEC 较为罕见，不到所有食管癌的 1%。目前的文献中关于先前照射过的区域发生食管癌的发病机制、诊断、治疗和结局的数据很少。RIEC 似乎代表了一种具有不良预后的侵袭性生物学疾病。尽管对先前照射过的区域进行根治性手术较为困难，但 R0 切除仍然是治疗的主要方法。新辅助和辅助放化疗在 RIEC 中的应用与常规食管癌方案类似，同样非常有帮助。本文的目的是阐明这一罕见但具有挑战性的实体。
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