Goffman T E, McKeen E A, Curtis R E, Schein P S
Cancer. 1983 Nov 15;52(10):1808-9. doi: 10.1002/1097-0142(19831115)52:10<1808::aid-cncr2820521008>3.0.co;2-w.
A patient previously irradiated for inner-quadrant breast cancer developed a midesophageal stricture that on repeated biopsies showed pathologic changes consistent with acute and chronic radiation injury. Eventually a focus of well-differentiated esophageal carcinoma was found in the stricture. The patient was the second in a series of 20 patients treated at Georgetown University Hospital, Medical Oncology Division, 1973-1978, for esophageal cancer, who gave a history of previous irradiation for breast carcinoma. This finding led to the review of related case reports, follow-up studies on irradiated spondylitic patients, and data from the Connecticut Tumor Registry on esophageal cancer following breast carcinoma. These data suggest that the modest increase in risk for esophageal cancer reported in studies of atomic bomb survivors is of clinical significance to patients receiving therapeutic radiation, and, that specifically, women irradiated for inner-quadrant breast cancer, in which the dose of radiation to the esophagus can be large, may be at risk for subsequent esophageal carcinoma.
一名曾接受内象限乳腺癌放疗的患者出现了食管中段狭窄，多次活检显示病理改变与急慢性放射损伤一致。最终在狭窄处发现了高分化食管癌灶。该患者是1973年至1978年在乔治敦大学医院肿瘤内科接受食管癌治疗的20例患者中的第二例，这些患者都有乳腺癌放疗史。这一发现促使对相关病例报告、脊柱病放疗患者的随访研究以及康涅狄格肿瘤登记处关于乳腺癌后食管癌的数据进行回顾。这些数据表明，原子弹幸存者研究中报告的食管癌风险适度增加对接受治疗性放疗的患者具有临床意义，具体而言，接受内象限乳腺癌放疗的女性，其食管接受的辐射剂量可能很大，可能有患后续食管癌的风险。
