The Metabolic Profile of L. Differs According to Its Associated Arbuscular Mycorrhizal Fungi.

(L.) interacts with various microorganisms including arbuscular mycorrhizal fungi (AMF). Recently, the AMF MUCL 41833 has been shown to modulate the metabolome of . However, little information is available on the impact that different AMF species may have on primary and secondary plant metabolites. In this study, four AMF species belonging to the genus ( MUCL 41833, MUCL 49410, MUCL 46238, MUCL 49408), were evaluated for their potential to modulate metabolome under controlled semi-hydroponic cultivation conditions. An untargeted metabolomic analysis was performed using UHPLC-HRMS followed by a multivariate data analysis. Forty-two compounds were reported to be highly modulated in relation to the different AMF associations. Among them, six new secondary metabolites were tentatively identified including two acetyl- and four malonyl- phenylpropanoid and saponin derivatives, all presenting a common substitution at position C-6 of the glycosidic moiety. In addition, an enhanced accumulation of primary and secondary metabolites was observed for and , showing a stronger effect on metabolome compared to and . Therefore, our data suggest that different AMF species may specifically modulate metabolite production.