Godbole Suneeta, Bowler Russell P
Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA.
Division of Medicine, National Jewish Health, Denver, CO 80206, USA.
Metabolites. 2022 Jul 5;12(7):621. doi: 10.3390/metabo12070621.
Chronic obstructive pulmonary disease (COPD) is a complex heterogeneous disease state with multiple phenotypic presentations that include chronic bronchitis and emphysema. Although COPD is a lung disease, it has systemic manifestations that are associated with a dysregulated metabolome in extrapulmonary compartments (e.g., blood and urine). In this scoping review of the COPD metabolomics literature, we identified 37 publications with a primary metabolomics investigation of COPD phenotypes in human subjects through Google Scholar, PubMed, and Web of Science databases. These studies consistently identified a dysregulation of the TCA cycle, carnitines, sphingolipids, and branched-chain amino acids. Many of the COPD metabolome pathways are confounded by age and sex. The effects of COPD in young versus old and male versus female need further focused investigations. There are also few studies of the metabolome's association with COPD progression, and it is unclear whether the markers of disease and disease severity are also important predictors of disease progression.
慢性阻塞性肺疾病（COPD）是一种复杂的异质性疾病状态，具有多种表型表现，包括慢性支气管炎和肺气肿。虽然COPD是一种肺部疾病，但它具有全身表现，与肺外腔室（如血液和尿液）中代谢组失调有关。在本次对COPD代谢组学文献的范围综述中，我们通过谷歌学术、PubMed和科学网数据库，确定了37篇对人类受试者COPD表型进行初级代谢组学研究的出版物。这些研究一致发现三羧酸循环、肉碱、鞘脂和支链氨基酸存在失调。许多COPD代谢组途径受到年龄和性别的混淆。COPD在年轻人与老年人以及男性与女性中的影响需要进一步的针对性研究。关于代谢组与COPD进展的关联研究也很少，目前尚不清楚疾病和疾病严重程度的标志物是否也是疾病进展的重要预测指标。
