Australian Centre for Ecogenomics, School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, Australia.
Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute, and The University of Newcastle, Newcastle, NSW, Australia.
Nat Commun. 2020 Nov 18;11(1):5886. doi: 10.1038/s41467-020-19701-0.
Chronic obstructive pulmonary disease (COPD) is the third commonest cause of death globally, and manifests as a progressive inflammatory lung disease with no curative treatment. The lung microbiome contributes to COPD progression, but the function of the gut microbiome remains unclear. Here we examine the faecal microbiome and metabolome of COPD patients and healthy controls, finding 146 bacterial species differing between the two groups. Several species, including Streptococcus sp000187445, Streptococcus vestibularis and multiple members of the family Lachnospiraceae, also correlate with reduced lung function. Untargeted metabolomics identifies a COPD signature comprising 46% lipid, 20% xenobiotic and 20% amino acid related metabolites. Furthermore, we describe a disease-associated network connecting Streptococcus parasanguinis_B with COPD-associated metabolites, including N-acetylglutamate and its analogue N-carbamoylglutamate. While correlative, our results suggest that the faecal microbiome and metabolome of COPD patients are distinct from those of healthy individuals, and may thus aid in the search for biomarkers for COPD.
慢性阻塞性肺疾病（COPD）是全球第三大致死原因，表现为一种进行性炎症性肺部疾病，目前尚无治愈方法。肺部微生物组与 COPD 的进展有关，但肠道微生物组的功能尚不清楚。在这里，我们检查了 COPD 患者和健康对照组的粪便微生物组和代谢组，发现两组之间有 146 种细菌存在差异。一些物种，包括链球菌 sp000187445、前庭链球菌和厚壁菌门的多个成员，也与肺功能下降有关。非靶向代谢组学确定了一个 COPD 特征，包括 46%的脂质、20%的外源性化合物和 20%的与氨基酸相关的代谢物。此外，我们还描述了一个与疾病相关的网络，将咽峡炎链球菌与 COPD 相关的代谢物（包括 N-乙酰谷氨酸及其类似物 N-碳酰谷氨酸）联系起来。虽然是相关的，但我们的结果表明，COPD 患者的粪便微生物组和代谢组与健康个体不同，因此可能有助于寻找 COPD 的生物标志物。
