Levi Gabrielle, Lurie-Weinberger Mor, Keren-Paz Alona, Andremont Antoine O, Schwartz David, Carmeli Yehuda
National Institute for Antibiotic Resistance and Infection Control, Ministry of Health, Tel Aviv 6423906, Israel.
Microbiology Department, Université Paris Diderot, Sorbonne Paris Cité, 75018 Paris, France.
Microorganisms. 2022 Jun 25;10(7):1292. doi: 10.3390/microorganisms10071292.
Antibiotic-resistant bacteria, and more specifically, carbapenem-producing Enterobacterales (CPE) strains, are increasing worldwide. Despite their growing prevalence, in most high-income countries, the detection of CPE is still considered a low-frequency event. Sporadically, patients co-colonized with distinct CPE strains and/or different carbapenemase enzymes are detected. In this paper, we present three cases that illustrate the underlying mechanisms of co-colonization, focusing on horizontal gene transfer (HGT) and patient-to-patient transmission. We also demonstrate the diversity of CPE species and discuss the potential consequences of co-colonization.
耐抗生素细菌，更具体地说，产碳青霉烯类肠杆菌科（CPE）菌株在全球范围内不断增加。尽管其流行率不断上升，但在大多数高收入国家，CPE的检测仍被视为低频事件。偶尔会检测到同时携带不同CPE菌株和/或不同碳青霉烯酶的患者。在本文中，我们介绍了三个案例，阐述了共同定植的潜在机制，重点是水平基因转移（HGT）和患者间传播。我们还展示了CPE物种的多样性，并讨论了共同定植的潜在后果。
