基于四频带超材料的等离子体完美吸收器生物传感器的实验研究。
Experimental Study of a Quad-Band Metamaterial-Based Plasmonic Perfect Absorber as a Biosensor.
机构信息
Department of Computer Engineering, Bandirma Onyedi Eylul University, Balikesir 10200, Turkey.
Biomedical Science and Engineering, Koc University, Istanbul 34450, Turkey.
出版信息
Molecules. 2022 Jul 18;27(14):4576. doi: 10.3390/molecules27144576.
We present a metamaterial-based perfect absorber (PA) that strongly supports four resonances covering a wide spectral range from 1.8 µm to 10 µm of the electromagnetic spectrum. The designed perfect absorber has metal-dielectric-metal layers where a MgF spacer is sandwiched between an optically thick gold film and patterned gold nanoantennas. The spectral tuning of PA is achieved by calibrating the geometrical parameters numerically and experimentally. The manufactured quad-band plasmonic PA absorbs light close to the unity. Moreover, the biosensing capacity of the PA is tested using a 14 kDa S100A9 antibody, which is a clinically relevant biomarker for brain metastatic cancer cells. We utilize a UV-based photochemical immobilization technique for patterning of the antibody monolayer on a gold surface. Our results reveal that the presented PA is eligible for ultrasensitive detection of such small biomarkers in a point-of-care device to potentially personalize radiotherapy for patients with brain metastases.
我们提出了一种基于超材料的完美吸收体（PA），它强烈支持四个共振，涵盖了从电磁频谱的 1.8 µm 到 10 µm 的宽光谱范围。设计的完美吸收体具有金属-介电-金属层，其中 MgF 间隔层夹在光学厚金膜和图案化金纳米天线之间。通过数值和实验校准几何参数来实现 PA 的光谱调谐。制造的四频带等离子体 PA 接近完全吸收光。此外，还使用 14 kDa S100A9 抗体测试了 PA 的生物传感能力，该抗体是脑转移癌细胞的临床相关生物标志物。我们利用基于 UV 的光化学固定化技术在金表面上对抗体单层进行图案化。我们的结果表明，所提出的 PA 适合在即时护理设备中对这种小生物标志物进行超灵敏检测，以潜在地为脑转移患者的放射治疗进行个性化定制。
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