School of Nursing, University of São Paulo, São Paulo 05403-000, Brazil.
Nutrients. 2022 Jul 7;14(14):2798. doi: 10.3390/nu14142798.
Chronic kidney disease (CKD) and acute kidney injury (AKI) are global health problems that affect over 850 million people, twice the number of diabetic individuals around the world. Diabetes mellitus (DM) is known to increase the susceptibility to AKI. Plants and foods, such as curcumin, are traditionally used as treatments for various diseases due to its wide range of bioactive compounds that exert antioxidative, anti-inflammatory, antimicrobial and anticancer properties. The aim of this study is to evaluate the effect of curcumin in diabetic rats with AKI. Adult male Wistar rats, weighing between 250 and 290 g, were randomized into four groups: Citrate (citrate buffer, i.v., single dose, on Day 1 of the protocol); DM (streptozotocin (STZ), 65 mg/k, single dose, i.v., on Day 1); DM + I/R (DM rats that, on Day 26, had the renal pedicle clamped for 30 min on both sides); DM + I/R + Curcumin (DM + I/R rats submitted to curcumin treatment). Results showed that IR worsened renal function and oxidative stress in DM rats, but the DM + IR + Curcumin group showed an increase in inulin clearance and a decrease in serum creatinine and in NGAL, in addition to an improvement in renal hemodynamics. These effects were accompanied by a reduction in oxidative and nitrosative metabolites and an increase in the thiol antioxidant reserve when curcumin was administered to the DM + IR group.
慢性肾病（CKD）和急性肾损伤（AKI）是全球性健康问题，影响着全球超过 8.5 亿人，是全球糖尿病患者人数的两倍。糖尿病（DM）已知会增加 AKI 的易感性。植物和食物，如姜黄素，由于其广泛的生物活性化合物具有抗氧化、抗炎、抗菌和抗癌特性，因此被传统上用作各种疾病的治疗方法。本研究旨在评估姜黄素对糖尿病合并 AKI 大鼠的作用。成年雄性 Wistar 大鼠，体重在 250 至 290 克之间，随机分为四组：柠檬酸盐（柠檬酸盐缓冲液，iv，单次剂量，在方案的第 1 天）；DM（链脲佐菌素（STZ），65mg/kg，iv，单次剂量，在第 1 天）；DM + I/R（在第 26 天肾脏蒂被夹闭两侧 30 分钟的 DM 大鼠）；DM + I/R + 姜黄素（接受姜黄素治疗的 DM + I/R 大鼠）。结果表明，IR 加重了 DM 大鼠的肾功能和氧化应激，但 DM + IR + 姜黄素组的菊粉清除率增加，血清肌酐和 NGAL 降低，此外，还改善了肾脏血液动力学。这些作用伴随着氧化和硝化代谢物的减少以及 DM + IR 组给予姜黄素时硫醇抗氧化储备的增加。
