Fernández-de-Las-Peñas César, Cancela-Cilleruelo Ignacio, Rodríguez-Jiménez Jorge, Gómez-Mayordomo Victor, Pellicer-Valero Oscar J, Martín-Guerrero José D, Hernández-Barrera Valentín, Arendt-Nielsen Lars, Torres-Macho Juan
Department of Physical Therapy, Occupational Therapy, Physical Medicine and Rehabilitation, Universidad Rey Juan Carlos (URJC), 28922 Madrid, Spain.
CNAP, Center for Sensory-Motor Interaction (SMI), Department of Health Science and Technology, Faculty of Medicine, Aalborg University, 9220 Aalborg, Denmark.
Pathogens. 2022 Jun 25;11(7):725. doi: 10.3390/pathogens11070725.
This study compared associated-symptoms at the acute phase of infection and post-COVID-19 symptoms between individuals hospitalized with the Wuhan, Alpha or Delta SARS-CoV-2 variant. Non-vaccinated individuals hospitalized because of SARS-CoV-2 infection in one hospital during three different waves of the pandemic (Wuhan, Alpha or Delta) were scheduled for a telephone interview. The presence of post-COVID-19 symptoms was systematically assessed. Hospitalization and clinical data were collected from medical records. A total of 201 patients infected with the Wuhan variant, 211 with the Alpha variant and 202 with Delta variant were assessed six months after hospitalization. Patients infected with the Wuhan variant had a greater number of symptoms at hospital admission (higher prevalence of fever, dyspnea or gastrointestinal problems) than those infected with Alpha or Delta variant (p < 0.01). A greater proportion of patients infected with the Delta variant reported headache, anosmia or ageusia as onset symptoms (p < 0.01). The mean number of post-COVID-19 symptoms was higher (p < 0.001) in individuals infected with the Wuhan variant (mean: 2.7 ± 1.3) than in those infected with the Alpha (mean: 1.8 ± 1.1) or Delta (mean: 2.1 ± 1.5) variant. Post-COVID-19 dyspnea was more prevalent (p < 0.001) in people infected with the Wuhan variant, whereas hair loss was higher in those infected with the Delta variant (p = 0.002). No differences in post-COVID-19 fatigue by SARS-CoV-2 variant were found (p = 0.594). Differences in COVID-19 associated onset symptoms and post-COVID-19 dyspnea were observed depending on the SARS-CoV-2 variant. The presence of fatigue was a common post-COVID-19 symptom to all SARS-CoV-2 variants.
本研究比较了感染武汉株、阿尔法株或德尔塔株严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的住院患者在感染急性期的相关症状以及感染新冠病毒后的症状。在疫情的三个不同阶段（武汉株、阿尔法株或德尔塔株流行期），对一家医院因SARS-CoV-2感染住院的未接种疫苗个体进行电话访谈。系统评估感染新冠病毒后的症状。从病历中收集住院和临床数据。共对201例感染武汉株、211例感染阿尔法株和202例感染德尔塔株的患者在住院6个月后进行评估。感染武汉株的患者入院时症状更多（发热、呼吸困难或胃肠道问题的患病率更高），高于感染阿尔法株或德尔塔株的患者（p<0.01）。感染德尔塔株的患者中，报告头痛、嗅觉丧失或味觉丧失为首发症状的比例更高（p<0.01）。感染武汉株的个体感染新冠病毒后的平均症状数更高（p<0.001）（平均：2.7±1.3），高于感染阿尔法株（平均：1.8±1.1）或德尔塔株（平均：2.1±1.5）的个体。感染新冠病毒后呼吸困难在感染武汉株的人群中更为普遍（p<0.001），而脱发在感染德尔塔株的人群中更高（p=0.002）。未发现不同SARS-CoV-2毒株感染后疲劳情况存在差异（p=0.594）。观察到不同SARS-CoV-2毒株在新冠病毒相关首发症状和感染新冠病毒后呼吸困难方面存在差异。疲劳是所有SARS-CoV-2毒株感染新冠病毒后的常见症状。
