Kociszewska-Najman Bożena, Jaskólska Magdalena, Taradaj Karol, Sibanda Elopy, Ginda Tomasz
Department of Neonatology and Rare Diseases, Faculty of Health Sciences, Medical University of Warsaw, 02-091 Warszawa, Poland.
Faculty of Medicine, National University of Science and Technology in Bulawayo, Bulawayo P.O. Box AC 909, Zimbabwe.
Vaccines (Basel). 2022 Jul 7;10(7):1089. doi: 10.3390/vaccines10071089.
The global response to the COVID-19 pandemic has been successfully driven by efforts to ramp up access to vaccines. Pregnant or breastfeeding women and their children have not benefited from the vaccines despite their susceptibility to the virus. We investigated whether women who were offered vaccination after delivery passively transferred protective antibodies to their infants via breast milk. Serum was collected from breast feeding mother-infant pairs and analysed for levels of antibodies to the SARS-CoV-2 spike protein using the CLIA chemiluminescence technique. Data were analysed for the significance of the differences using the Mann-Whitney U test and the Spearman's rank correlation coefficient to determine the strength of the correlation. A total of 13 mothers, mean age 34.86 (95%CI = 33.21-36.48) years and their infants, mean age 15.77 (95%CI = 11.24-20.29) months were enrolled. The mothers had completed their courses of the mRNA BNT162b2 SARS-CoV-2 vaccine during breastfeeding, 8.3 (95%CI = 7.24-9.36) months before the study. All 13 mothers had detectable antibodies to the SARS-CoV-2 spike protein, mean 1252, (95%CI = 736-1769) BAU/mL. Antibodies were detected in 3/13 (23%) breast-fed infants mean 322, (95%CI = 252-897) BAU/mL. There was no correlation between the maternal and infant IgG antibody titres. The time-lag since full vaccination did not correlate to the presence of antibodies in infant sera. Maternal or infant ages did not correlate to the presence of antibodies. Although some children (23%) had anti-SARS-CoV-2 antibodies, there was no association between vaccine-induced COVID-19 spike protein specific maternal IgG antibody titres and the presence of antibodies in the breastfed infants. The data show that the transfer of passive immunity to infants following post-partum vaccination with the mRNA BNT162b2 SARS-CoV-2 vaccine may be infrequent in this population.
全球对新冠疫情的应对工作因加大疫苗接种力度而取得了成功。尽管孕妇、哺乳期妇女及其子女易感染新冠病毒，但他们尚未从疫苗接种中受益。我们调查了产后接种疫苗的妇女是否通过母乳将保护性抗体被动转移给了她们的婴儿。采集了母乳喂养的母婴对的血清，并使用CLIA化学发光技术分析了针对新冠病毒刺突蛋白的抗体水平。使用曼-惠特尼U检验和斯皮尔曼等级相关系数分析数据差异的显著性，以确定相关性的强度。共招募了13名母亲，平均年龄34.86岁（95%置信区间=33.21-36.48岁）及其婴儿，平均年龄15.77个月（95%置信区间=11.24-20.29个月）。母亲们在母乳喂养期间完成了mRNA BNT162b2新冠病毒疫苗的接种疗程，即在研究前8.3个月（95%置信区间=7.24-9.36个月）。所有13名母亲均检测到针对新冠病毒刺突蛋白的抗体，平均为1252（95%置信区间=736-1769）BAU/mL。在13名母乳喂养婴儿中有3名（23%）检测到抗体，平均为322（95%置信区间=252-897）BAU/mL。母婴IgG抗体滴度之间没有相关性。完全接种疫苗后的时间间隔与婴儿血清中抗体的存在没有相关性。母亲或婴儿的年龄与抗体的存在没有相关性。尽管一些儿童（23%）具有抗新冠病毒抗体，但疫苗诱导的新冠病毒刺突蛋白特异性母亲IgG抗体滴度与母乳喂养婴儿中抗体的存在之间没有关联。数据表明，在这一人群中，产后接种mRNA BNT162b2新冠病毒疫苗后向婴儿被动转移被动免疫的情况可能并不常见。
