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伊比利亚鼹鼠中cathelicidin衍生肽的抗菌活性

Antimicrobial Activity of Cathelicidin-Derived Peptide from the Iberian Mole .

作者信息

Otazo-Pérez Andrea, Asensio-Calavia Patricia, González-Acosta Sergio, Baca-González Victoria, López Manuel R, Morales-delaNuez Antonio, Pérez de la Lastra José Manuel

机构信息

Biotechnology of Macromolecules Research Group, Instituto de Productos Naturales y Agrobiología (IPNA-CSIC), Avda. Astrofísico Francisco Sánchez, 3, 38206 San Cristóbal de la Laguna, Spain.

Escuela de Doctorado y Estudios de Posgrado, Universidad de La Laguna, Avda. Astrofísico Francisco Sánchez, SN. Edificio Calabaza-Apdo. 456, 38200 San Cristóbal de La Laguna, Spain.

出版信息

Vaccines (Basel). 2022 Jul 10;10(7):1105. doi: 10.3390/vaccines10071105.

DOI:10.3390/vaccines10071105
PMID:35891269
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9323388/
Abstract

The immune systems of all vertebrates contain cathelicidins, a family of antimicrobial peptides. Cathelicidins are a type of innate immune effector that have a number of biological functions, including a well-known direct antibacterial action and immunomodulatory function. In search of new templates for antimicrobial peptide discovery, we have identified and characterized the cathelicidin of the small mammal . We describe the heterogeneity of cathelicidin in the order in relation to the Iberian mole and predict its antibacterial activity using bioinformatics tools. In an effort to correlate these findings, we derived the putative active peptide and performed in vitro hemolysis and antimicrobial activity assays, confirming that Iberian mole cathelicidins are antimicrobial. Our results showed that the Iberian mole putative peptide, named To-KL37 (KLFGKVGNLLQKGWQKIKNIGRRIKDFFRNIRPMQEA) has antibacterial and antifungal activity. Understanding the antimicrobial defense of insectivores may help scientists prevent the spread of pathogens to humans. We hope that this study can also provide new, effective antibacterial peptides for future drug development.

摘要

所有脊椎动物的免疫系统都包含cathelicidins，这是一类抗菌肽。Cathelicidins是一种先天免疫效应物，具有多种生物学功能，包括众所周知的直接抗菌作用和免疫调节功能。为了寻找发现抗菌肽的新模板，我们已经鉴定并表征了这种小型哺乳动物的cathelicidin。我们描述了猬形目动物中cathelicidin相对于伊比利亚鼹鼠的异质性，并使用生物信息学工具预测了其抗菌活性。为了关联这些发现，我们推导了假定的活性肽，并进行了体外溶血和抗菌活性测定，证实伊比利亚鼹鼠的cathelicidins具有抗菌作用。我们的结果表明，伊比利亚鼹鼠的假定肽，命名为To-KL37（KLFGKVGNLLQKGWQKIKNIGRRIKDFFRNIRPMQEA）具有抗菌和抗真菌活性。了解食虫动物的抗菌防御可能有助于科学家防止病原体传播给人类。我们希望这项研究也能为未来的药物开发提供新的、有效的抗菌肽。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71d9/9323388/e7654badf4a6/vaccines-10-01105-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71d9/9323388/909668c929bb/vaccines-10-01105-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71d9/9323388/983edd94e29d/vaccines-10-01105-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71d9/9323388/3e77183f7c43/vaccines-10-01105-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71d9/9323388/36f32d128e27/vaccines-10-01105-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71d9/9323388/97cef57d2aa3/vaccines-10-01105-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71d9/9323388/6caba0839b72/vaccines-10-01105-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71d9/9323388/1f2f2a36d790/vaccines-10-01105-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71d9/9323388/af6d24a263f0/vaccines-10-01105-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71d9/9323388/e7654badf4a6/vaccines-10-01105-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71d9/9323388/909668c929bb/vaccines-10-01105-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71d9/9323388/983edd94e29d/vaccines-10-01105-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71d9/9323388/3e77183f7c43/vaccines-10-01105-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71d9/9323388/36f32d128e27/vaccines-10-01105-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71d9/9323388/97cef57d2aa3/vaccines-10-01105-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71d9/9323388/6caba0839b72/vaccines-10-01105-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71d9/9323388/1f2f2a36d790/vaccines-10-01105-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71d9/9323388/af6d24a263f0/vaccines-10-01105-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71d9/9323388/e7654badf4a6/vaccines-10-01105-g009.jpg

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本文引用的文献

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2
ColabFold: making protein folding accessible to all.ColabFold：让蛋白质折叠变得人人可用。
Nat Methods. 2022 Jun;19(6):679-682. doi: 10.1038/s41592-022-01488-1. Epub 2022 May 30.
3
Evolving and assembling to pierce through: Evolutionary and structural aspects of antimicrobial peptides.不断进化与组装以实现穿透：抗菌肽的进化与结构方面
活性物质在固有免疫中的作用。
Vaccines (Basel). 2022 Oct 17;10(10):1735. doi: 10.3390/vaccines10101735.
Comput Struct Biotechnol J. 2022 May 10;20:2247-2258. doi: 10.1016/j.csbj.2022.05.002. eCollection 2022.
4
Spatial arrangement of proteins in planar and curved membranes by PPM 3.0.PPM 3.0 对平面和弯曲膜中蛋白质的空间排布。
Protein Sci. 2022 Jan;31(1):209-220. doi: 10.1002/pro.4219. Epub 2021 Nov 8.
5
Physicochemical Features and Peculiarities of Interaction of AMP with the Membrane.AMP与膜相互作用的物理化学特征及特性
Pharmaceuticals (Basel). 2021 May 17;14(5):471. doi: 10.3390/ph14050471.
6
Bioinformatic Analysis of Genome-Predicted Bat Cathelicidins.基因组预测的蝙蝠 cathelicidins 的生物信息学分析。
Molecules. 2021 Mar 23;26(6):1811. doi: 10.3390/molecules26061811.
7
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Pathogens. 2021 Feb 4;10(2):165. doi: 10.3390/pathogens10020165.
8
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9
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10
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