Hatami Maryam, Förster Moritz, Weyers Vivien, Räuber Saskia, Meuth Sven G, Kremer David
Department of Neurology, University Hospital Düsseldorf, Medical Faculty, Heinrich Heine University, 40225 Düsseldorf, Germany.
Vaccines (Basel). 2022 Jul 16;10(7):1132. doi: 10.3390/vaccines10071132.
Neuromyotonia is a rare peripheral nerve hyperexcitability syndrome often associated with antibodies directed against contactin-associated protein-like 2 and leucine-rich, glioma inactivated 1. The quadrivalent human papilloma virus vaccine Gardasil, first approved in 2006, is known to be a highly effective prophylaxis against papillomavirus types 6, 11, 16, and 18. Molecularly, this non-infectious recombinant vaccine is based on purified L1 proteins from the human papilloma virus capsid. Since the approval of this vaccine, several studies have investigated its safety regarding the occurrence of autoimmune conditions following application. Here, we present the first case of neuromyotonia with active Gadolinium enhancing demyelinating central nervous system lesions following vaccination with Gardasil.
神经性肌强直是一种罕见的周围神经兴奋性增高综合征，常与针对接触蛋白相关蛋白样2和富含亮氨酸的胶质瘤失活蛋白1的抗体有关。四价人乳头瘤病毒疫苗加德西于2006年首次获批，已知对6、11、16和18型乳头瘤病毒具有高效预防作用。从分子层面来看，这种非感染性重组疫苗基于人乳头瘤病毒衣壳中纯化的L1蛋白。自该疫苗获批以来，多项研究调查了其接种后自身免疫性疾病发生的安全性。在此，我们报告首例接种加德西疫苗后出现伴有钆增强脱髓鞘性中枢神经系统病变的神经性肌强直病例。
