Buigues Jaime, Viñals Adrià, Martínez-Recio Raquel, Monrós Juan S, Sanjuán Rafael, Cuevas José M
Institute for Integrative Systems Biology (I2SysBio), Universitat de València and Consejo Superior de Investigaciones Científicas, 46980 València, Spain.
Institut Cavanilles de Biodiversitat i Biologia Evolutiva, Universitat de València, 46980 València, Spain.
Viruses. 2024 Dec 5;16(12):1885. doi: 10.3390/v16121885.
Viromics studies are allowing us to understand not only the enormous diversity of the virosphere, but also the potential threat posed by the emerging viruses. Regarding the latter, the main concern lies in monitoring the presence of RNA viruses, but the zoonotic potential of some DNA viruses, on which we have focused in the present study, should also be highlighted. For this purpose, we analyzed 160 fecal samples from 14 species of small terrestrial mammals, 9 of them belonging to the order . This allowed us to identify a total of 25 complete or near-complete genomes belonging to the families , , , , and , 18 of which could be considered new species or types. Our results provide a significant increase in the number of complete genomes of DNA viruses of European origin with zoonotic potential in databases, which are at present under-represented compared to RNA viruses. In addition, the characterization of whole genomes is of relevance for the further study of the evolutionary forces governing virus adaptation, such as recombination, which may play an important role in cross-species transmission.
病毒组学研究不仅使我们能够了解病毒圈的巨大多样性，还能让我们认识到新兴病毒带来的潜在威胁。关于后者，主要关注点在于监测RNA病毒的存在，但我们在本研究中重点关注的一些DNA病毒的人畜共患病潜力也应得到重视。为此，我们分析了来自14种小型陆生哺乳动物的160份粪便样本，其中9种属于 目。这使我们总共鉴定出了25个完整或近乎完整的基因组，它们分别属于 科、 科、 科、 科和 科，其中18个可被视为新物种或新类型。我们的研究结果显著增加了数据库中具有人畜共患病潜力的欧洲起源DNA病毒完整基因组的数量，与RNA病毒相比，目前这些DNA病毒在数据库中的代表性不足。此外，全基因组的特征描述对于进一步研究控制病毒适应性的进化力量（如重组）具有重要意义，重组可能在跨物种传播中发挥重要作用。
