Microbe Evolution Phylogeny Infection, Institut pour la Recherche et le Developpement, Assistance Publique Hopitaux de Marseille, Aix-Marseille University, 13005 Marseille, France.
Institue Hospitalo, Universitaire Mediterranée Infection, 13005 Marseille, France.
Viruses. 2022 Jul 9;14(7):1507. doi: 10.3390/v14071507.
During the last two years following the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, development of potent antiviral drugs and vaccines has been a global health priority. In this context, the understanding of virus pathophysiology, the identification of associated therapeutic targets, and the screening of potential effective compounds have been indispensable advancements. It was therefore of primary importance to develop experimental models that recapitulate the aspects of the human disease in the best way possible. This article reviews the information concerning available SARS-CoV-2 preclinical models during that time, including cell-based approaches and animal models. We discuss their evolution, their advantages, and drawbacks, as well as their relevance to drug effectiveness evaluation.
在严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 大流行后的近两年，开发有效的抗病毒药物和疫苗一直是全球卫生的重点。在这方面，对病毒病理生理学的理解、相关治疗靶点的确定以及潜在有效化合物的筛选是必不可少的进展。因此，开发尽可能再现人类疾病特征的实验模型至关重要。本文综述了在此期间有关 SARS-CoV-2 临床前模型的信息，包括基于细胞的方法和动物模型。我们讨论了它们的演变、优缺点，以及它们在评估药物疗效方面的相关性。
