Li Yuan, Li Yucong, Li Linlong, Wang Haixing, Wang Bin, Feng Lu, Lin Sien, Li Gang
Department of Orthopaedics & Traumatology, Stem Cells and Regenerative Medicine Laboratory, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, SAR, PR China.
Bioland Laboratory, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou, PR China.
J Orthop Translat. 2022 Apr 19;34:113-120. doi: 10.1016/j.jot.2022.03.005. eCollection 2022 May.
Chronic skin wounds impose immense suffers and economic burdens. Current research mainly focuses on acute wound management which exhibits less effective in chronic wound healing. Growth differentiation factor 11 (GDF11) has profound effects on several important physiological processes related to chronic wound healing, such as inflammation, cell proliferation, migration, angiogenesis, and neurogenesis. This review summarizes recent advances in biology of chronic wounds and the potential role of GDF11 on wound healing with its regenerative effects, as well as the potential delivery methods of GDF11. The challenges and future perspectives of GDF11-based therapy for chronic wound care are also discussed. The Translational Potential of this Article: This review summarized the significance of GDF11 in the modulation of inflammation, vascularization, cell proliferation, and remodeling, which are important physiological processes of chronic wound healing. The potential delivery methods of GDF11 in the management of chronic wound healing is also summarized. This review may provide potential therapeutic approaches based on GDF11 for chronic wound healing.
慢性皮肤伤口带来巨大痛苦和经济负担。当前研究主要集中在急性伤口处理上，而这在慢性伤口愈合中效果欠佳。生长分化因子11（GDF11）对与慢性伤口愈合相关的几个重要生理过程具有深远影响，如炎症、细胞增殖、迁移、血管生成和神经发生。本综述总结了慢性伤口生物学的最新进展以及GDF11通过其再生作用在伤口愈合中的潜在作用，以及GDF11的潜在递送方法。还讨论了基于GDF11的慢性伤口护理治疗的挑战和未来前景。本文的转化潜力：本综述总结了GDF11在调节炎症、血管生成、细胞增殖和重塑方面的重要性，这些是慢性伤口愈合的重要生理过程。还总结了GDF11在慢性伤口愈合管理中的潜在递送方法。本综述可能为基于GDF11的慢性伤口愈合提供潜在的治疗方法。
