Rizzato G, Tosi G, Mella C, Zanni D, Sisti S, Loglisci T
Sarcoidosis. 1987 Mar;4(1):45-8.
Eighty-four normal subjects, 5 untreated sarcoid patients and 32 sarcoid patients under chronic prednisone therapy were submitted to Quantitative Computed Tomography (QCT) for Vertebral Cancellous Mineral Content (VCMC) evaluation. In the five untreated and in the 84 normal subjects, VCMC (given in mg/cm3) fell in the normal range found elsewhere. 22 of the 32 treated patients had lower than normal values. Osteoporosis (expressed through cancellous mineral loss) increased significantly (P less than .01) with increasing dose x time of prednisone therapy. We conclude that the bone loss is far more frequent than suspected in prednisone treated patients with sarcoidosis; yearly QCT could be a good tool for monitoring patients under chronic therapy.
84名正常受试者、5名未经治疗的结节病患者和32名接受慢性泼尼松治疗的结节病患者接受了定量计算机断层扫描（QCT）以评估椎体松质骨矿物质含量（VCMC）。在5名未经治疗的患者和84名正常受试者中，VCMC（以mg/cm³为单位）处于其他地方发现的正常范围内。32名接受治疗的患者中有22名的值低于正常水平。随着泼尼松治疗剂量×时间的增加，骨质疏松症（通过松质骨矿物质流失表示）显著增加（P小于0.01）。我们得出结论，在接受泼尼松治疗的结节病患者中，骨质流失比怀疑的要频繁得多；每年进行QCT可能是监测长期治疗患者的一个好工具。
