Rizzato G, Montemurro L
Sarcoid Clinic, Niguarda Hospital, Milan, Italy.
Eur Respir J. 1993 Jan;6(1):116-9.
Osteoporosis is not usually considered to be reversible, as it is a consequence of the ageing process. However, an improvement of bone mineral density after successful surgery in Cushing's syndrome has been shown in several reports. The question of reversibility of exogenous corticosteroid-induced osteoporosis is, as yet, unanswered, possibly because of the difficulty in discontinuing steroids after long-term use. We describe six patients, all under 45 yrs of age, with chronic long-standing sarcoidosis, in whom long-term prednisone therapy resulted in 15 +/- 7% bone loss, as evaluated by quantitative computed tomography. This side-effect appeared fully reversible after prednisone withdrawal. This report of the reversibility of exogenous corticosteroid-induced bone loss needs confirmation in elderly people, where the capacity for recovery of bone mass could be reduced. Such potential for recovery may have implications for the pattern of use of corticosteroids.
骨质疏松症通常被认为是不可逆的，因为它是衰老过程的结果。然而，几份报告显示，库欣综合征患者成功手术后骨矿物质密度有所改善。外源性皮质类固醇所致骨质疏松症的可逆性问题至今尚无答案，这可能是因为长期使用类固醇后难以停药。我们描述了6例年龄均在45岁以下的慢性长期结节病患者，通过定量计算机断层扫描评估，长期泼尼松治疗导致他们骨质流失15±7%。停用泼尼松后，这种副作用似乎完全可逆。外源性皮质类固醇所致骨质流失的这种可逆性报告需要在老年人中得到证实，因为老年人的骨量恢复能力可能会降低。这种恢复潜力可能会对皮质类固醇的使用模式产生影响。
