Yang Yuhe, Rao Jingdong, Liu Huaqian, Dong Zhifei, Zhang Zhen, Bei Ho-Pan, Wen Chunyi, Zhao Xin
Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hung Hom, Hong Kong, China.
Faculty of Science, University of Waterloo, Waterloo, Ontario, Canada.
J Orthop Translat. 2022 Jul 11;36:18-32. doi: 10.1016/j.jot.2022.05.013. eCollection 2022 Sep.
Periosteum is a vascularized tissue membrane covering the bone surface and plays a decisive role in bone reconstruction process after fracture. Various artificial periosteum has been developed to assist the allografts or bionic bone scaffolds in accelerating bone healing. Recently, the biomimicking design of artificial periosteum has attracted increasing attention due to the recapitulation of the natural extracellular microenvironment of the periosteum and has presented unique capacity to modulate the cell fates and ultimately enhance the bone formation and improve neovascularization.
A systematic literature search is performed and relevant findings in biomimicking design of artificial periosteum have been reviewed and cited.
We give a systematical overview of current development of biomimicking design of artificial periosteum. We first summarize the universal strategies for designing biomimicking artificial periosteum including biochemical biomimicry and biophysical biomimicry aspects. We then discuss three types of novel versatile biomimicking artificial periosteum including physical-chemical combined artificial periosteum, heterogeneous structured biomimicking periosteum, and healing phase-targeting biomimicking periosteum. Finally, we comment on the potential implications and prospects in the future design of biomimicking artificial periosteum.
This review summarizes the preparation strategies of biomimicking artificial periosteum in recent years with a discussion of material selection, animal model adoption, biophysical and biochemical cues to regulate the cell fates as well as three types of latest developed versatile biomimicking artificial periosteum. In future, integration of innervation, osteochondral regeneration, and osteoimmunomodulation, should be taken into consideration when fabricating multifunctional artificial periosteum.: This study provides a holistic view on the design strategy and the therapeutic potential of biomimicking artificial periosteum to promote bone healing. It is hoped to open a new avenue of artificial periosteum design with biomimicking considerations and reposition of the current strategy for accelerated bone healing.
骨膜是覆盖在骨表面的血管化组织膜，在骨折后的骨重建过程中起决定性作用。人们已研发出各种人工骨膜，以辅助同种异体移植物或仿生骨支架加速骨愈合。近年来，人工骨膜的仿生设计因重现了骨膜的天然细胞外微环境而备受关注，并且展现出独特的调节细胞命运的能力，最终增强骨形成并改善新生血管形成。
进行了系统的文献检索，并对人工骨膜仿生设计的相关研究结果进行了综述和引用。
我们对人工骨膜仿生设计的当前发展进行了系统概述。我们首先总结了设计仿生人工骨膜的通用策略，包括生化仿生和生物物理仿生方面。然后，我们讨论了三种新型多功能仿生人工骨膜，包括物理 - 化学复合人工骨膜、异质结构仿生骨膜和愈合阶段靶向仿生骨膜。最后，我们对仿生人工骨膜未来设计的潜在影响和前景进行了评论。
本综述总结了近年来仿生人工骨膜的制备策略，讨论了材料选择、动物模型应用、调节细胞命运的生物物理和生化线索以及三种最新开发的多功能仿生人工骨膜。未来，在制造多功能人工骨膜时应考虑神经支配、骨软骨再生和骨免疫调节的整合。本研究提供了关于仿生人工骨膜促进骨愈合的设计策略和治疗潜力的整体观点。希望能开辟一条考虑仿生因素的人工骨膜设计新途径，并重新定位当前加速骨愈合的策略。
