Guangdong Province Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou, China.
School of Clinical Medicine, Chengdu Medical College, Chengdu, China.
J Cell Physiol. 2022 Oct;237(10):3705-3716. doi: 10.1002/jcp.30841. Epub 2022 Jul 26.
As one of the most important organs in animals, the intestine is responsible for nutrient absorption and acts as a barrier between the body and the environment. Intestinal physiology and function require the participation of energy. 5'-adenosine monophosphate-activated protein kinase (AMPK), a classical and highly expressed energy regulator in intestinal cells, regulates the process of nutrient absorption and barrier function and is also involved in the therapy of intestinal diseases. Studies have yielded findings that AMPK regulates the absorption of glucose, amino acids, and fatty acids in the intestine primarily by regulating transportation systems, as we detailed here. Moreover, AMPK is involved in the regulation of the intestinal mechanical barrier and immune barrier through manipulating the expression of tight junctions, antimicrobial peptides, and secretory immunoglobulins. In addition, AMPK also participates in the regulation of intestinal diseases, which indicates that AMPK is a promising therapeutic target for intestinal diseases and cancer. In this review, we summarized the current understanding regarding how AMPK regulates intestinal nutrient absorption, barrier function, and intestinal diseases.
作为动物最重要的器官之一，肠道负责营养吸收，并在体内和环境之间起到屏障作用。肠道的生理和功能需要能量的参与。5'-腺苷一磷酸激活蛋白激酶 (AMPK) 是肠道细胞中经典且高度表达的能量调节剂，调节营养吸收和屏障功能的过程，也参与肠道疾病的治疗。研究发现，AMPK 主要通过调节运输系统来调节肠道对葡萄糖、氨基酸和脂肪酸的吸收，我们在这里详细介绍了这一点。此外，AMPK 通过调节紧密连接、抗菌肽和分泌型免疫球蛋白的表达来参与肠道机械屏障和免疫屏障的调节。此外，AMPK 还参与肠道疾病的调节，这表明 AMPK 是肠道疾病和癌症有希望的治疗靶点。在这篇综述中，我们总结了目前对 AMPK 如何调节肠道营养吸收、屏障功能和肠道疾病的理解。
