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颞骨内面神经鞘瘤:单中心45例病例回顾

Intratemporal Facial Nerve Schwannomas: A Review of 45 Cases in A Single Center.

作者信息

Kitama Tsubasa, Hosoya Makoto, Noguchi Masaru, Nishiyama Takanori, Wakabayashi Takeshi, Shimanuki Marie N, Yazawa Masaki, Inoue Yasuhiro, Kanzaki Jin, Ogawa Kaoru, Oishi Naoki

机构信息

Department of Otorhinolaryngology-Head and Neck Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.

Department of Plastic Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.

出版信息

Diagnostics (Basel). 2022 Jul 23;12(8):1789. doi: 10.3390/diagnostics12081789.

Abstract

There are no established indications for facial nerve schwannoma treatment, including surgery, radiation and follow-up observation, and it is difficult to determine treatment policy uniformly. The treatment policy was examined from each treatment course. Data of patients with facial nerve schwannomas at our hospital from 1987 to 2018 were retrospectively examined. Their age, sex, clinical symptoms, tumor localization, treatment policies and outcomes were reviewed. In total, 22 patients underwent surgery and 1 patient underwent radiotherapy; 22 patients were followed up without treatment. After total resection, there were no tumor recurrences, and most patients had grade 3 or 4 postoperative facial paralysis. After subtotal resection, tumor regrowth was observed in four patients and reoperation was required in two patients. Facial nerve function was maintained in four patients and was decreased in two patients. During follow-up, six patients showed tumor growth. Only one patient had worsening facial nerve paralysis; four patients underwent facial nerve decompression owing to facial nerve paralysis during follow-up. If the tumor compresses the brain or it is prone to growth, surgery may be indicated, and when the preoperative facial nerve function is grade ≤3, consideration should be given to preserving facial nerve function and subtotal resection should be indicated. If the preoperative facial nerve function is grade ≥3, total resection with nerve grafting is an option to prevent regrowth. If there is no brain compression or tumor growth, the follow-up is a good indication, and decompression should be considered in facial nerve paralysis cases.

摘要

目前尚无公认的面神经鞘瘤治疗指征,包括手术、放疗及随访观察,因此难以统一确定治疗策略。本研究从各个治疗过程对治疗策略进行了探讨。回顾性分析了我院1987年至2018年收治的面神经鞘瘤患者的数据,对其年龄、性别、临床症状、肿瘤定位、治疗策略及治疗结果进行了分析。共有22例患者接受了手术治疗,1例患者接受了放疗;22例患者未接受治疗仅进行随访观察。肿瘤全切术后无肿瘤复发,但多数患者术后出现3级或4级面瘫。次全切术后,4例患者出现肿瘤复发,2例患者需要再次手术。4例患者面神经功能得以保留,2例患者面神经功能减退。随访期间,6例患者肿瘤生长。仅1例患者面神经麻痹加重;4例患者因随访期间出现面神经麻痹而接受了面神经减压术。如果肿瘤压迫脑组织或易于生长,则可能需要手术治疗,当术前面神经功能分级≤3级时,应考虑保留面神经功能并进行次全切术。如果术前面神经功能分级≥3级,可选择行肿瘤全切并进行神经移植以防止肿瘤复发。如果没有脑组织受压或肿瘤生长,随访观察是较好的选择,对于面神经麻痹患者应考虑进行减压术。

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