Péus Dominik, Sellathurai Shaumiya, Newcomb Nicolas, Tschopp Kurt, Radeloff Andreas
Department of Otorhinolaryngology, University of Oldenburg, 26122 Oldenburg, Germany.
Department of Otorhinolaryngology, Cantonal Hospital Baselland, 4410 Liestal, Switzerland.
Audiol Res. 2022 Jul 5;12(4):377-387. doi: 10.3390/audiolres12040038.
This systematic review investigates ear cooling and cryotherapy in the prevention and treatment of inner ear damage and disease, within the context of animal models and clinical studies. A literature search was carried out in the databases Pubmed and Cochrane Library. Ten studies were identified concerning the otoprotective properties of cryotherapy. Nine of these were rodent in vivo studies (mice, rats, gerbils, guinea pigs). One study involved human subjects and investigated cryotherapy in idiopathic sensorineural hearing loss. The studies were heterogeneous in their goals, methods, and the models used. Disorder models included ischemia and noise damage, ototoxicity (cisplatin and aminoglycoside), and CI-electrode insertion. All ten studies demonstrated significant cryotherapeutic otoprotection for their respective endpoints. No study revealed or expressly investigated otodestructive effects. While limited in number, all of the studies within the scope of the review demonstrated some degree of cryotherapeutic, otoprotective effect. These promising results support the conducting of further work to explore and refine the clinical applicability and impact of cryotherpeutics in otolaryngology.
本系统评价在动物模型和临床研究的背景下，研究耳部冷却和冷冻疗法在预防和治疗内耳损伤及疾病方面的作用。在PubMed和Cochrane图书馆数据库中进行了文献检索。共确定了10项关于冷冻疗法耳保护特性的研究。其中9项是啮齿动物体内研究（小鼠、大鼠、沙鼠、豚鼠）。1项研究涉及人类受试者，并调查了冷冻疗法治疗特发性感音神经性听力损失的情况。这些研究在目标、方法和使用的模型方面存在异质性。疾病模型包括缺血和噪声损伤、耳毒性（顺铂和氨基糖苷类）以及人工耳蜗电极植入。所有10项研究均表明冷冻疗法对其各自的终点具有显著的耳保护作用。没有研究揭示或明确调查耳破坏作用。虽然数量有限，但本综述范围内的所有研究均显示出一定程度的冷冻疗法耳保护作用。这些有前景的结果支持开展进一步的工作，以探索和完善冷冻疗法在耳鼻喉科的临床适用性和影响。
