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体外冲击波疗法（ESWT）会减少大鼠正中神经用静脉内肌肉导管修复后的轴突再生，但自体神经移植后则不会。

ESWT Diminishes Axonal Regeneration following Repair of the Rat Median Nerve with Muscle-In-Vein Conduits but Not after Autologous Nerve Grafting.

作者信息

Heinzel Johannes C, Oberhauser Viola, Keibl Claudia, Schädl Barbara, Swiadek Nicole V, Längle Gregor, Frick Helen, Slezak Cyrill, Prahm Cosima, Grillari Johannes, Kolbenschlag Jonas, Hercher David

机构信息

Department of Hand, Plastic, Reconstructive and Burn Surgery, BG Klinik Tuebingen, University of Tuebingen, Schnarrenbergstraße 95, 72076 Tuebingen, Germany.

Ludwig Boltzmann Institute for Traumatology, The Research Center in Cooperation with AUVA, Donaueschingenstraße 13, 1200 Vienna, Austria.

出版信息

Biomedicines. 2022 Jul 22;10(8):1777. doi: 10.3390/biomedicines10081777.

DOI:10.3390/biomedicines10081777
PMID:35892677
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9394363/
Abstract

Investigations reporting positive effects of extracorporeal shockwave therapy (ESWT) on nerve regeneration are limited to the rat sciatic nerve model. The effects of ESWT on muscle-in-vein conduits (MVCs) have also not been investigated yet. This study aimed to evaluate the effects of ESWT after repair of the rat median nerve with either autografts (ANGs) or MVCs. In male Lewis rats, a 7 mm segment of the right median nerve was reconstructed either with an ANG or an MVC. For each reconstructive technique, one group of animals received one application of ESWT while the other rats served as controls. The animals were observed for 12 weeks, and nerve regeneration was assessed using computerized gait analysis, the grasping test, electrophysiological evaluations and histological quantification of axons, blood vessels and lymphatic vasculature. Here, we provide for the first time a comprehensive analysis of ESWT effects on nerve regeneration in a rat model of median nerve injury. Furthermore, this study is among the first reporting the quantification of lymphatic vessels following peripheral nerve injury and reconstruction in vivo. While we found no significant direct positive effects of ESWT on peripheral nerve regeneration, results following nerve repair with MVCs were significantly inferior to those after ANG repair.

摘要

报告体外冲击波疗法（ESWT）对神经再生有积极作用的研究仅限于大鼠坐骨神经模型。ESWT对静脉内肌肉导管（MVC）的影响也尚未得到研究。本研究旨在评估ESWT对大鼠正中神经采用自体移植（ANG）或MVC修复后的影响。在雄性Lewis大鼠中，用ANG或MVC重建右侧正中神经7mm节段。对于每种重建技术，一组动物接受一次ESWT治疗，而其他大鼠作为对照。观察动物12周，并使用计算机化步态分析、抓握试验、电生理评估以及轴突、血管和淋巴管系统的组织学定量来评估神经再生。在此，我们首次对ESWT对正中神经损伤大鼠模型中神经再生的影响进行了全面分析。此外，本研究是最早报道体内周围神经损伤和重建后淋巴管定量的研究之一。虽然我们发现ESWT对周围神经再生没有明显的直接积极作用，但MVC修复神经后的结果明显不如ANG修复后。

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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff1d/9394363/264f6d452e8f/biomedicines-10-01777-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff1d/9394363/1da1958a742b/biomedicines-10-01777-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff1d/9394363/ff1fd9dcef95/biomedicines-10-01777-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff1d/9394363/75d2c02695cb/biomedicines-10-01777-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff1d/9394363/7fe0aa10968d/biomedicines-10-01777-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff1d/9394363/d1d56c1be681/biomedicines-10-01777-g010.jpg
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