Giammalva Giuseppe Roberto, Brunasso Lara, Paolini Federica, Costanzo Roberta, Bonosi Lapo, Benigno Umberto Emanuele, Ferini Gianluca, Sava Serena, Colarossi Cristina, Umana Giuseppe Emmanuele, Gerardi Rosa Maria, Sturiale Carmelo Lucio, Albanese Alessio, Iacopino Domenico Gerardo, Maugeri Rosario
Neurosurgical Clinic, AOUP "Paolo Giaccone", Post Graduate Residency Program in Neurologic Surgery, Department of Biomedicine Neurosciences and Advanced Diagnostics, School of Medicine, University of Palermo, 90127 Palermo, Italy.
Department of Radiation Oncology, REM Radioterapia srl, 95125 Catania, Italy.
Cancers (Basel). 2022 Jul 26;14(15):3639. doi: 10.3390/cancers14153639.
The role of immunotherapy is gaining ever-increasing interest in the neuro-oncological field, and this is also expanding to the management of intracranial meningioma. Meningiomas are still the most common primary adult tumor of the CNS, and even though surgery and/or radiotherapy still represent cornerstones of their treatment, recent findings strongly support the potential role of specific immune infiltrate cells, their features and genomics, for the application of personalized treatments and prognostic implications. According to the PRISMA guidelines, systematic research in the most updated platform was performed in order to provide a descriptive and complete overview about the characteristics, role and potential implications of immunology in meningioma tumors. Seventy articles were included and analyzed in the present paper. The meningioma microenvironment reveals complex immune tumor-immune cells interactions that may definitely influence tumor progression, as well as offering unexpected opportunities for treatment.
免疫疗法在神经肿瘤学领域正越来越受到关注，并且这一领域也在扩展到颅内脑膜瘤的治疗。脑膜瘤仍是中枢神经系统最常见的原发性成人肿瘤，尽管手术和/或放疗仍是其治疗的基石，但最近的研究结果有力地支持了特定免疫浸润细胞及其特征和基因组学在个性化治疗应用和预后方面的潜在作用。根据PRISMA指南，在最新平台上进行了系统研究，以便对免疫学在脑膜瘤肿瘤中的特征、作用和潜在影响提供描述性和完整的概述。本文纳入并分析了70篇文章。脑膜瘤微环境揭示了复杂的肿瘤-免疫细胞相互作用，这肯定会影响肿瘤进展，同时也为治疗提供了意想不到的机会。
