胸腺生成中的胸腺细胞外基质：仅仅是一种支持物吗？
Thymic Extracellular Matrix in the Thymopoiesis: Just a Supporting?
作者信息
Lins Marvin Paulo
机构信息
Laboratory of Cell Biology, Institute of Biological and Health Sciences, Federal University of Alagoas, Maceió 57072-970, Brazil.
Brazilian National Institute of Science and Technology on Neuroimmunomodulation (INCT-NIM), Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro 21040-360, Brazil.
出版信息
BioTech (Basel). 2022 Jul 18;11(3):27. doi: 10.3390/biotech11030027.
The generation of T lymphocytes (thymopoiesis) is one of the major functions of the thymus that occurs throughout life. Thymic epithelial cells actively participate in this process. However, less attention has been paid to extracellular matrix (ECM) elements of thymus and their role in thymocyte differentiation. To clarify this topic, we selected some studies that deal with thymic ECM, its modulation, and its effects on thymopoiesis in different models. We emphasize that further studies are needed in order to deepen this knowledge and to propose new alternatives for thymic ECM functions during thymopoiesis.
T淋巴细胞的生成（胸腺生成）是胸腺贯穿一生的主要功能之一。胸腺上皮细胞积极参与这一过程。然而，人们对胸腺的细胞外基质（ECM）成分及其在胸腺细胞分化中的作用关注较少。为阐明这一主题，我们挑选了一些涉及胸腺ECM、其调节及其在不同模型中对胸腺生成影响的研究。我们强调，需要进一步开展研究，以深化这方面的知识，并为胸腺生成过程中胸腺ECM的功能提出新的见解。
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