Department of Obstetrics and Gynecology, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania.
Filantropia Clinical Hospital, 011132 Bucharest, Romania.
Medicina (Kaunas). 2022 Jul 23;58(8):984. doi: 10.3390/medicina58080984.
Pulmonary Alveolar Proteinosis (PAP) is a rare, usually autoimmune, disease, where surfactant accumulates within alveoli due to decreased clearance, causing dyspnea and hypoxemia. The disease is even more rare in pregnancy; nevertheless, it has been reported in pregnant women and can even appear for the first time during pregnancy as an asthma-like illness. Therefore, awareness is important. Similarly to many autoimmune diseases, it can worsen during pregnancy and postpartum, causing maternal and fetal/neonatal complications. This paper offers a narrative literature review of PAP and pregnancy, while illustrating a case of a pregnant patient with known PAP who developed preeclampsia in the third trimester but had an overall fortunate maternal and neonatal outcome.
肺泡蛋白沉积症（PAP）是一种罕见的、通常为自身免疫性疾病，由于清除减少，表面活性剂在肺泡内积聚，导致呼吸困难和低氧血症。该病在妊娠中更为罕见；然而，已经有报道称妊娠妇女中也会发生该病，甚至可能在妊娠期间首次表现为哮喘样疾病。因此，提高认识很重要。与许多自身免疫性疾病一样，该病在妊娠和产后期间可能会恶化，导致母婴和胎儿/新生儿并发症。本文对 PAP 和妊娠进行了叙述性文献回顾，同时说明了一例患有已知 PAP 的妊娠患者，她在妊娠晚期发生子痫前期，但母婴结局总体幸运。
