Division of Hospital Medicine, Department of Medicine, Washington University School of Medicine, 4523 Clayton Avenue, CB 8058, St Louis, MO 63110, USA.
Division of Cardiovascular Medicine, Department of Medicine, Washington University School of Medicine, 660 South Euclid Avenue, CB 8086, St Louis, MO 63110, USA.
Cardiol Clin. 2021 Feb;39(1):109-118. doi: 10.1016/j.ccl.2020.09.007. Epub 2020 Oct 29.
Pulmonary arterial hypertension is a rare disease that predominantly affects women. The pathophysiology of the disease is complex, with both genetic and hormonal influences. Pregnancy causes significant physiologic changes that may not be well tolerated with underlying pulmonary arterial hypertension, in particular leading to volume overload and increased pulmonary pressures. A multidisciplinary approach and careful monitoring are essential for appropriate management of pulmonary arterial hypertension during pregnancy. Nonetheless, outcomes are still poor, and pregnancy is considered a contraindication in patients with pulmonary arterial hypertension.
肺动脉高压是一种罕见的疾病，主要影响女性。该疾病的病理生理学较为复杂，受遗传和激素的影响。妊娠会引起显著的生理变化，而这些变化可能无法很好地耐受潜在的肺动脉高压，特别是会导致血容量过载和肺动脉压升高。在妊娠期间，对肺动脉高压进行适当管理需要多学科的方法和仔细的监测。尽管如此，结局仍然较差，且妊娠被认为是肺动脉高压患者的禁忌症。
