Ciobanu Anca Marina, Dumitru Andreea Elena, Gica Nicolae, Botezatu Radu, Peltecu Gheorghe, Panaitescu Anca Maria
Filantropia Clinical Hospital, Bucharest 11171, Romania.
Carol Davila University of Medicine and Pharmacy, Bucharest 020021, Romania.
Diagnostics (Basel). 2020 Aug 12;10(8):583. doi: 10.3390/diagnostics10080583.
Maternal passage of immunoglobulin G (IgG) is an important passive mechanism for protecting the infant while the neonatal immune system is still immature and ineffective. IgG is the only antibody class capable of crossing the histological layers of the placenta by attaching to the neonatal Fc receptor expressed at the level of syncytiotrophoblasts, and it offers protection against neonatal infectious pathogens. In pregnant women with autoimmune or alloimmune disorders, or in those requiring certain types of biological therapy, transplacental passage of abnormal antibodies may cause fetal or neonatal harm. In this review, we will discuss the physiological mechanisms and benefits of transplacental transfer of maternal antibodies as well as pathological maternal situations where this system is hijacked, potentially leading to adverse neonatal outcomes.
免疫球蛋白G（IgG）通过母体传递是一种重要的被动机制，可在新生儿免疫系统仍不成熟且无功能时保护婴儿。IgG是唯一能够通过附着在合体滋养层水平表达的新生儿Fc受体上穿过胎盘组织层的抗体类别，它为新生儿提供针对感染性病原体的保护。在患有自身免疫或同种免疫疾病的孕妇中，或在那些需要某些类型生物疗法的孕妇中，异常抗体的经胎盘传递可能会对胎儿或新生儿造成伤害。在本综述中，我们将讨论母体抗体经胎盘转移的生理机制和益处，以及该系统被利用从而可能导致不良新生儿结局的母体病理情况。
