Citu Cosmin, Gorun Oana Maria, Motoc Andrei, Citu Ioana Mihaela, Gorun Florin, Malita Daniel
Department of Obstetrics and Gynecology, "Victor Babes" University of Medicine and Pharmacy Timisoara, 2 Eftimie Murgu Square, 300041 Timisoara, Romania.
Department of Obstetrics and Gynecology, Municipal Emergency Clinical Hospital Timisoara, 1-3 Alexandru Odobescu Street, 300202 Timisoara, Romania.
J Clin Med. 2022 Jul 25;11(15):4299. doi: 10.3390/jcm11154299.
(1) Background: This study aims to evaluate the association of CRP, NLR, IL-6, and Procalcitonin with lung damage observed on CT scans; (2) Methods: A cross-sectional study was performed among 106 COVID-19 patients hospitalized in Timisoara Municipal Emergency Hospital. Chest CT and laboratory analysis were performed in all patients. The rank Spearmen correlation was used to assess the association between inflammatory markers and lung involvement. In addition, ROC curve analysis was used to determine the accuracy of inflammatory markers in the diagnosis of severe lung damage; (3) Results: CRP, NLR, and IL-6 were significantly positively correlated with lung damage. All inflammatory markers had good accuracy for diagnosis of severe lung involvement. Moreover, IL-6 has the highest AUC- ROC curve; (4) Conclusions: The inflammatory markers are associated with lung damage and can be used to evaluate COVID-19 severity.
(1) 背景：本研究旨在评估C反应蛋白（CRP）、中性粒细胞与淋巴细胞比值（NLR）、白细胞介素-6（IL-6）和降钙素原与CT扫描观察到的肺损伤之间的关联；(2) 方法：在蒂米什瓦拉市急诊医院住院的106例新冠病毒病（COVID-19）患者中进行了一项横断面研究。对所有患者进行了胸部CT和实验室分析。采用Spearman秩相关分析来评估炎症标志物与肺部受累之间的关联。此外，采用ROC曲线分析来确定炎症标志物在诊断严重肺损伤中的准确性；(3) 结果：CRP、NLR和IL-6与肺损伤显著正相关。所有炎症标志物对严重肺部受累的诊断具有良好的准确性。此外，IL-6的AUC-ROC曲线最高；(4) 结论：炎症标志物与肺损伤相关，可用于评估COVID-19的严重程度。
