Caiazza S, Fanizza C, Ferrari M
Rev Fr Transfus Immunohematol. 1986 Dec;29(6):455-63. doi: 10.1016/s0338-4535(86)80077-0.
In spite of the great interest in developing a perfluorocarbon (PFC) blood substitute with a wide range of applications, the in vivo and in vitro knowledge of the interactions between PFCs and cells, from the ultrastructural point of view is limited up to now. In this framework, our observation confirmed the PFC particle uptake by rat hepatocytes in vivo as well as in vitro. The absence of endocytosis by rat and guinea pig myocytes in vivo, to be confirmed by in vitro experiments, could favour a safe use of PFCs as components of cardioplegic solutions.
尽管人们对开发具有广泛应用的全氟化碳（PFC）血液替代品有着浓厚兴趣，但迄今为止，从超微结构角度来看，关于PFC与细胞之间相互作用的体内和体外知识仍然有限。在此框架下，我们的观察证实了大鼠肝细胞在体内和体外均可摄取PFC颗粒。大鼠和豚鼠心肌细胞在体内不存在内吞作用，这一点有待体外实验证实，这可能有利于安全使用PFC作为心脏停搏液的成分。
