Motta G, Ratto G B, Spinelli E, Agati R, Sacco A, Poloniato G
Minerva Med. 1981 Jan 28;72(3):167-72.
A fluorocarbonate emulsion was infused into 30 rabbits after the removal of varying amounts of blood. Parameters relating to the transport of respiratory gases and the fundamental features of the macrocirculation were monitored. The animals were sacrificed after 6 or 24 hr and the histological changes in the main parenchymas were assessed. The material injected displayed low toxicity, a good ability to act as a vehicle for oxygen and carbon dioxide, and no tendency to alter the macrocirculation. Numerous problems remain, however, with regard to the stability of fluorocarbonates over the course of time and the effect of their uptake by tissues.
在抽取不同量的血液后，将一种氟碳酸盐乳剂注入30只兔子体内。监测与呼吸气体运输以及大循环基本特征相关的参数。在6小时或24小时后处死动物，并评估主要实质器官的组织学变化。注入的物质显示出低毒性、作为氧气和二氧化碳载体的良好能力，并且没有改变大循环的倾向。然而，关于氟碳酸盐随时间的稳定性及其被组织摄取的影响，仍然存在许多问题。
