Stäuble Céline K, Jeiziner Chiara, Bollinger Anna, Wiss Florine M, Hatzinger Martin, Hersberger Kurt E, Ihde Thomas, Lampert Markus L, Mikoteit Thorsten, Meyer Zu Schwabedissen Henriette E, Allemann Samuel S
Pharmaceutical Care, Department of Pharmaceutical Sciences, University of Basel, 4056 Basel, Switzerland.
Institute of Hospital Pharmacy, Solothurner Spitäler AG, 4600 Olten, Switzerland.
Pharmacy (Basel). 2022 Jul 19;10(4):86. doi: 10.3390/pharmacy10040086.
Genetic predisposition is one factor influencing interindividual drug response. Pharmacogenetic information can be used to guide the selection and dosing of certain drugs. However, the implementation of pharmacogenetics (PGx) in clinical practice remains challenging. Defining a formal structure, as well as concrete procedures and clearly defined responsibilities, may facilitate and increase the use of PGx in clinical practice. Over 140 patient cases from an observational study in Switzerland formed the basis for the design and refinement of a pharmacist-led pharmacogenetics testing and counselling service (PGx service) in an interprofessional setting. Herein, we defined a six-step approach, including: (1) patient referral; (2) pre-test-counselling; (3) PGx testing; (4) medication review; (5) counselling; (6) follow-up. The six-step approach supports the importance of an interprofessional collaboration and the role of pharmacists in PGx testing and counselling across healthcare settings.
遗传易感性是影响个体间药物反应的一个因素。药物遗传学信息可用于指导某些药物的选择和剂量确定。然而，药物遗传学（PGx）在临床实践中的实施仍然具有挑战性。定义一个正式的结构，以及具体的程序和明确的职责，可能会促进并增加PGx在临床实践中的应用。来自瑞士一项观察性研究的140多个患者病例构成了在跨专业环境中由药剂师主导的药物遗传学检测和咨询服务（PGx服务）设计和完善的基础。在此，我们定义了一个六步方法，包括：（1）患者转诊；（2）检测前咨询；（3）PGx检测；（4）用药审查；（5）咨询；（6）随访。该六步方法支持跨专业协作的重要性以及药剂师在跨医疗环境的PGx检测和咨询中的作用。
