Pharmaceutical Care Research Group, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, 4056, Basel, Switzerland.
Biopharmacy, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, 4056, Basel, Switzerland.
Int J Clin Pharm. 2023 Dec;45(6):1378-1386. doi: 10.1007/s11096-023-01596-8. Epub 2023 Jun 20.
Pharmacogenetic (PGx) testing and counselling (short: PGx service) in the community pharmacy is not routinely practiced. We propose a comprehensive pharmacist-led service where PGx information is integrated into medication reviews.
To evaluate the pharmacist-led service comprising PGx testing and counselling (PGx service) from the perspective of patients.
For this mixed-methods study, we conducted two follow-up interviews F1 and F2 with patients recruited for the PGx service in a community pharmacy after 1st of January 2020. The semi-structured interviews were held by phone call and covered understanding of PGx, the implementation of recommendations, handling of PGx documents (list of concerned substances and PGx recommendation), gain in medication knowledge, and willingness to pay for the PGx service.
We interviewed 25 patients in F1 and 42 patients in F2. Patients were generally able to understand and use results of the PGx service. At least one PGx recommendation was implemented for 69% of the patients. Handling of PGx documents ranged from patients having forgotten about the PGx results to patients consulting the list for every medication-related decision; the latter often expecting negative effects. Finally, 62% of the patients were willing to pay for the PGx service.
For future PGx testing and counselling, HCPs should consider the patients' health literacy in a standardized way and use adequate communication skills to enhance the patient's understanding in PGx and to attenuate potential negative expectations.
社区药房尚未常规开展药物遗传学（PGx）检测和咨询（简称 PGx 服务）。我们提出了一项全面的药剂师主导的服务，将 PGx 信息整合到药物审查中。
从患者的角度评估由药剂师主导的包括 PGx 检测和咨询（PGx 服务）的服务。
这项混合方法研究对 2020 年 1 月 1 日以后在社区药房接受 PGx 服务的患者进行了两次随访访谈 F1 和 F2。半结构化访谈通过电话进行，涵盖对 PGx 的理解、建议的实施、PGx 文档（相关物质清单和 PGx 建议）的处理、药物知识的增加以及对 PGx 服务的付费意愿。
我们在 F1 中采访了 25 名患者，在 F2 中采访了 42 名患者。患者普遍能够理解和使用 PGx 服务的结果。至少有一个 PGx 建议得到了 69%的患者的实施。PGx 文档的处理范围从患者忘记 PGx 结果到患者在每次与药物相关的决策中都咨询清单；后者通常期望有负面的影响。最后，62%的患者愿意为 PGx 服务付费。
对于未来的 PGx 检测和咨询，卫生保健专业人员应该以标准化的方式考虑患者的健康素养，并使用适当的沟通技巧，提高患者对 PGx 的理解，减轻潜在的负面预期。
