Liu Yifei, Söderberg Joakim, Chao Jingdong
Division of Pharmacy Practice and Administration, The University of Missouri-Kansas City School of Pharmacy, Kansas City, MO 64108, USA.
Health Solutions, 118 26 Stockholm, Sweden.
Pharmacy (Basel). 2022 Jul 20;10(4):87. doi: 10.3390/pharmacy10040087.
(1) to determine the adherence and persistence rates of adalimumab therapy among Swedish patients with Crohn's disease (CD), and (2) to compare self-administration devices to predict the medication adherence and persistence.
We conducted a retrospective analysis of the Swedish National Board of Health and Welfare database during a unique time period, when both the pen and the syringe were available. The pen was proposed to indicate a larger extent of internal control, according to health locus of control. Medication adherence was defined as a medication possession ratio (MPR) ≥ 0.8. A patient was considered nonpersistent if the time between any two dispensing records, minus the days of supply dispensed exceeded 180 days. The predictors of adherence were evaluated using a logistic regression, and the predictors of persistence were evaluated using a Cox proportional hazards model.
Among the 1083 patients studied, 89% were adherent and 77% were persistent. The patients using the pen and the patients treated in gastroenterology centers were more likely to be adherent and less likely to be nonpersistent.
The adherence rate to adalimumab therapy was 89% and the one-year persistence rate was 70%. The pen and treatment in a gastroenterology center had a positive impact on the adherence and persistence among Swedish patients with CD.
（1）确定瑞典克罗恩病（CD）患者中阿达木单抗治疗的依从率和持续率，以及（2）比较自我给药装置以预测药物依从性和持续性。
我们在一个独特的时间段内对瑞典国家卫生和福利委员会数据库进行了回顾性分析，当时笔式注射器和普通注射器均可使用。根据健康控制点，笔式注射器被认为能表明更大程度的内部控制。药物依从性定义为药物持有率（MPR）≥0.8。如果任意两次配药记录之间的时间减去所配药的供应天数超过180天，则该患者被视为非持续用药。使用逻辑回归评估依从性的预测因素，使用Cox比例风险模型评估持续性的预测因素。
在1083名研究患者中，89%的患者依从治疗，77%的患者持续用药。使用笔式注射器的患者和在胃肠病中心接受治疗的患者更有可能依从治疗且不太可能非持续用药。
阿达木单抗治疗的依从率为89%，一年持续率为70%。笔式注射器和在胃肠病中心接受治疗对瑞典CD患者的依从性和持续性有积极影响。
