Yamashita Yasunori, Mae Megumi, Oohira Masayuki, Ozaki Yukio, Ohba Seigo, Asahina Izumi, Yoshimura Atsutoshi
Department of Periodontology and Endodontology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki 852-8588, Japan.
Department of Regenerative Oral Surgery, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki 852-8588, Japan.
Pharmaceuticals (Basel). 2022 Jul 25;15(8):924. doi: 10.3390/ph15080924.
Antimicrobial photodynamic therapy (a-PDT) in combination with scaling root planing (SRP) is more effective at improving periodontal status than SRP alone. However, the effectiveness of a-PDT in combination with irrigation for patients undergoing periodontal maintenance has not been clarified. This study evaluated the efficacy and safety of a-PDT in the maintenance phase. Patients who had multiple sites with bleeding on probing (BOP) and periodontal probing depth (PPD) of 4-6 mm in the maintenance phase were treated with a split-mouth design. These sites were randomly assigned to one of two groups: the a-PDT group and the irrigation group. In the a-PDT group, the periodontal pockets were treated with light-sensitive toluidine blue and a light irradiator. In the irrigation group, the periodontal pockets were simply irrigated using an ultrasonic scaler. After 7 days, the safety and efficacy of a-PDT were assessed. The mean PPD of the a-PDT group had reduced from 4.50 mm to 4.13 mm, whereas negligible change was observed in the irrigation group. BOP significantly improved from 100% to 33% in the PDT group, whereas it hardly changed in the irrigation group. No adverse events were observed in any patients. a-PDT may be useful as a noninvasive treatment in the maintenance phase, especially in patients with relatively deep periodontal pocket.
抗菌光动力疗法（a-PDT）联合龈下刮治术（SRP）在改善牙周状况方面比单纯SRP更有效。然而，a-PDT联合冲洗对牙周维护期患者的有效性尚未明确。本研究评估了a-PDT在维护期的疗效和安全性。采用半口设计对维护期有多个探诊出血（BOP）部位且牙周探诊深度（PPD）为4-6mm的患者进行治疗。这些部位被随机分为两组：a-PDT组和冲洗组。a-PDT组用光敏性甲苯胺蓝和光照射器治疗牙周袋。冲洗组仅用超声洁牙器冲洗牙周袋。7天后，评估a-PDT的安全性和疗效。a-PDT组的平均PPD从4.50mm降至4.13mm，而冲洗组观察到的变化可忽略不计。PDT组的BOP从100%显著改善至33%，而冲洗组几乎没有变化。所有患者均未观察到不良事件。a-PDT作为维护期的一种非侵入性治疗方法可能有用，尤其是对于牙周袋相对较深的患者。
