Baldascino Antonio, Ripa Matteo, Carlà Matteo Mario, Caporossi Tomaso, Grieco Giulia, Gambini Gloria, De Vico Umberto, Raguso Giuseppe, Kilian Raphael, Rizzo Clara, Rizzo Stanislao
Ophthalmology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.
Ophthalmology Unit, Catholic University "Sacro Cuore", 00168 Rome, Italy.
Vision (Basel). 2022 Jun 24;6(3):38. doi: 10.3390/vision6030038.
Background: To investigate macular microvascular changes after uncomplicated phacoemulsification surgery according to the cataract severity grade. Methods: Retrospective, cross-sectional study involving 23 eyes of 23 patients who underwent elective cataract extraction. All patients underwent routine ophthalmologic examination, including optical coherence tomography angiography (OCTA) at baseline (preoperative visit, T0) and seven days postoperatively (T7). OCTA scans were obtained with the spectral domain system Cirrus 5000 (Carl Zeiss Meditec, Inc., Dublin, CA, USA), and 3 mm × 3 mm raster fovea-centered scans were obtained to evaluate the superficial capillary plexus (SCP) vessel density, perfusion density, and foveal avascular zone (FAZ) parameters. Results: SCP perfusion density significantly increased from 28.3 ± 5.73% to 33.74 ± 4.13% after the surgery (p < 0.001). Similarly, SCP vessel density significantly increased from 15.14 ± 3.41 mm−1 to 18.14 ± 2.57 mm−1 after surgery (p < 0.001). The mean preoperative FAZ area significantly increased from 0.27 ± 0.12 mm to 0.24 ± 0.11 mm seven days postoperatively (p = 0.008). When comparing softer and harder cataracts, no significant variations in SCP vessel density, as well as SCP perfusion density parameters and the FAZ area, perimeter, and circularity index, were noted before and after surgery. Conclusions: Macular SPC vessel density and macular SCP perfusion density increase after uncomplicated cataract surgery regardless of the cataract severity.
根据白内障严重程度分级，研究单纯超声乳化白内障吸除术后黄斑微血管的变化。方法：对23例接受择期白内障摘除术的患者的23只眼进行回顾性横断面研究。所有患者均接受常规眼科检查，包括在基线时（术前访视，T0）和术后7天（T7）进行光学相干断层扫描血管造影（OCTA）。使用Cirrus 5000光谱域系统（美国加利福尼亚州都柏林市卡尔蔡司医疗技术公司）进行OCTA扫描，并获取以黄斑中心凹为中心的3 mm×3 mm光栅扫描，以评估浅表毛细血管丛（SCP）血管密度、灌注密度和黄斑无血管区（FAZ）参数。结果：术后SCP灌注密度从28.3±5.73%显著增加至33.74±4.13%（p<0.001）。同样，术后SCP血管密度从15.14±3.41 mm−1显著增加至18.14±2.57 mm−1（p<0.001）。术后7天，术前平均FAZ面积从0.27±0.12 mm显著增加至0.24±0.11 mm（p=0.008）。在比较软白内障和硬白内障时，手术前后SCP血管密度、SCP灌注密度参数以及FAZ面积、周长和圆形度指数均无显著差异。结论：无论白内障严重程度如何，单纯白内障手术后黄斑SPC血管密度和黄斑SCP灌注密度均会增加。
