Furdova Alena, Vesely Pavol, Trnka Michal, Novakova Elena, Stubna Michal, Furda Robert, Branikova Lubica, Pridavkova Zuzana
Department of Ophthalmology, Faculty of Medicine, Comenius University, 826 01 Bratislava, Slovakia.
VESELY Eye Clinic, 826 00 Bratislava, Slovakia.
Vision (Basel). 2022 Jul 22;6(3):46. doi: 10.3390/vision6030046.
Since 2020, the COVID-19 (Coronavirus Disease 2019) has quickly become a worldwide health problem. Ophthalmologists must deal with symptoms as well. For the positive detection in the conjunctival sac swab in COVID-19 patients hospitalized in Slovakia during March 2021 in four hospital centers, we used a test based on a polymerase chain reaction (PCR). In a group of 484 patients, 264 males (55%) and 220 females (45%) with clinical symptoms were identified with COVID-19 as a clinical diagnosis. The PCR test swab results from the conjunctival sac taken on the same day were positive in 58 patients (12%), 31 males (with a mean age of 74.6 ± 13.59 years) and 27 females (with a mean age of 70.63 ± 14.17 years); negative in 417 patients (86%); and 9 patients (2%) had an unclear result. The cycle threshold values comparing the nasopharynx and conjunctiva were also different in the group of all patients divided by age and gender. In COVID-19 patients the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) was detectable using PCR test in the nasopharynx but also in the conjunctival sac swab, where the positivity rate was only 12%.
自2020年以来，新型冠状病毒肺炎（COVID-19，即2019冠状病毒病）迅速成为一个全球性的健康问题。眼科医生也必须应对相关症状。为了对2021年3月在斯洛伐克四个医院中心住院的COVID-19患者结膜囊拭子进行阳性检测，我们使用了基于聚合酶链反应（PCR）的检测方法。在一组484例患者中，有264例男性（55%）和220例女性（45%）出现临床症状，临床诊断为COVID-19。同一天采集的结膜囊PCR检测拭子结果显示，58例患者（12%）呈阳性，其中31例男性（平均年龄74.6±13.59岁），27例女性（平均年龄70.63±14.17岁）；417例患者（86%）呈阴性；9例患者（2%）结果不明。在按年龄和性别划分的所有患者组中，比较鼻咽部和结膜的循环阈值也有所不同。在COVID-19患者中，使用PCR检测可在鼻咽部以及结膜囊拭子中检测到严重急性呼吸综合征冠状病毒2（SARS-CoV-2），其中结膜囊拭子的阳性率仅为12%。
