Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, ON, Canada.
Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
Eur J Ophthalmol. 2021 Jul;31(4):1677-1687. doi: 10.1177/1120672121992949. Epub 2021 Feb 8.
To summarize COVID-19 research endeavors by ophthalmologists/researchers in terms of publication numbers, journals and author countries, and to detail key findings.
The LitCovid database was systematically reviewed for ophthalmology-focused COVID-19 articles. The quality of the evidence was assessed for articles investigating conjunctivitis in COVID-19 patients.
There were 21,364 articles in LitCovid on June 12, 2020, of which 215 (1%) were ophthalmology-focused. Of articles on COVID-19 transmission, 3.3% were ophthalmology-focused. Ophthalmology-focused articles were published in 68 journals and originated from 25 countries. The top five countries publishing ophthalmology-focused articles (China, India, United States of America, Italy, and United Kingdom) produced 145/215 (67%) articles. A total of 16 case reports/series from eight countries reported that conjunctivitis can be the initial or the only symptom of COVID-19 infection. Conjunctivitis may occur in the middle phase of COVID-19 illness. A total of 10 hospital-based cross-sectional studies reported that between 0% and 31.6% of COVID-19 patients have conjunctivitis or other ocular conditions, with a pooled prevalence of 5.5% reported in a meta-analysis. Viral RNA was detected in conjunctival swabs of patients with and without ocular manifestations, after resolution of conjunctivitis, after nasopharyngeal swabs turned negative and in retina of deceased COVID-19 patients.
Within 3 months of declaring the COVID-19 pandemic, 215 ophthalmology-focused articles were published in PubMed, concentrating on disease manifestations and transmission. The reported presence of conjunctivitis or other ocular conditions in COVID-19 patients is varied. Clinicians should be alert for ocular involvement in COVID-19 infections and possible ocular transmission even in patients without ocular symptoms.
根据出版物数量、期刊和作者所在国家，总结眼科医生/研究人员在 COVID-19 研究方面的工作，并详细说明主要发现。
系统地在 LitCovid 数据库中检索了聚焦于 COVID-19 的眼科文章。对于研究 COVID-19 患者结膜炎的文章，评估了证据的质量。
截至 2020 年 6 月 12 日，LitCovid 中有 21364 篇文章，其中 215 篇（1%）是聚焦于眼科的。在关于 COVID-19 传播的文章中，有 3.3%是聚焦于眼科的。聚焦于眼科的文章发表在 68 种期刊上，来自 25 个国家。发表聚焦于眼科文章的前五个国家（中国、印度、美国、意大利和英国）产生了 145/215（67%）的文章。来自八个国家的总共 16 篇病例报告/系列报告称，结膜炎可能是 COVID-19 感染的初始或唯一症状。结膜炎可能发生在 COVID-19 疾病的中期。总共 10 项基于医院的横断面研究报告称，0%至 31.6%的 COVID-19 患者有结膜炎或其他眼部疾病，荟萃分析报告的总患病率为 5.5%。在有和没有眼部表现的患者的结膜拭子中、在结膜炎消退后、在鼻咽拭子转为阴性后以及在死亡的 COVID-19 患者的视网膜中都检测到了病毒 RNA。
在宣布 COVID-19 大流行后的 3 个月内，在 PubMed 上发表了 215 篇聚焦于疾病表现和传播的眼科文章。报告称 COVID-19 患者存在不同程度的结膜炎或其他眼部疾病。临床医生应该警惕 COVID-19 感染的眼部受累，甚至在没有眼部症状的患者中也可能存在眼部传播。
