Brusini Romain, Iehl Julien, Clerc Elodie, Gallet Mélanie, Bourdon François, Faivre Jimmy
Research and Development Department, Teoxane SA, Rue de Lyon 105, 1203 Geneva, Switzerland.
Pharmaceutics. 2022 Jul 26;14(8):1553. doi: 10.3390/pharmaceutics14081553.
Hyaluronic acid-based filler injections are now well-established aesthetic procedures for the correction of skin tissue defects and volume loss. Filler injections are becoming increasingly popular, with a growing number of injections performed each year. Although classified as a minimally invasive procedure, the introduction of a needle or a canula may remain painful for the patient. A major improvement was achieved with the incorporation of local anesthetics into the formulation for pain relief.
In this study, two well-known anesthetics, lidocaine and mepivacaine, were systematically compared to assess their influence on filler mechanical and biological features. The impact of each anesthetic was monitored in terms of gel rheological properties, stability, durability, and degradation. The release profiles of each anesthetic were also recorded. Finally, the pharmacokinetics of each anesthetic in rats were assessed.
For all the rheological and biological experiments performed, lidocaine and mepivacaine influences were comparable. The addition of either anesthetic into a soft-tissue filler showed no significant modifications of the stability, durability, and degradability of the gel, with similar release profiles and pharmacokinetics at an equivalent concentration.
Substituting lidocaine with mepivacaine does not impact the properties of the gels, and thus both can be equally incorporated as anesthetics in soft-tissue fillers.
基于透明质酸的填充剂注射如今已成为矫正皮肤组织缺陷和容量缺失的成熟美容手术。填充剂注射越来越受欢迎，每年进行的注射数量不断增加。尽管被归类为微创手术，但针头或套管的插入对患者来说可能仍然很疼。通过在配方中加入局部麻醉剂来缓解疼痛取得了重大进展。
在本研究中，对两种知名麻醉剂利多卡因和甲哌卡因进行了系统比较，以评估它们对填充剂机械和生物学特性的影响。从凝胶流变学特性、稳定性、耐久性和降解方面监测每种麻醉剂的影响。还记录了每种麻醉剂的释放曲线。最后，评估了每种麻醉剂在大鼠体内的药代动力学。
对于所进行的所有流变学和生物学实验，利多卡因和甲哌卡因的影响相当。在软组织填充剂中添加任何一种麻醉剂，凝胶的稳定性、耐久性和降解性均无显著改变，在同等浓度下具有相似的释放曲线和药代动力学。
用甲哌卡因替代利多卡因不会影响凝胶的特性，因此两者均可同等地作为麻醉剂加入软组织填充剂中。
