流变学作为研究透明质酸真皮填充剂降解性的工具
Rheology as a Tool to Investigate the Degradability of Hyaluronic Acid Dermal Fillers.
作者信息
Grimaldi Giulia, Galasso Giulia, Capillo Maria Chiara, Alonci Giuseppe, Bighetti Stefano, Bettolini Luca, Sommatis Sabrina, Mocchi Roberto, Carugno Andrea, Zerbinati Nicola
机构信息
UB-CARE S.r.l.-Spin-Off, University of Pavia, Pavia, Italy.
Dermatology Department, University of Brescia, ASST Spedali Civili di Brescia, Brescia, Italy.
出版信息
Clin Cosmet Investig Dermatol. 2025 May 31;18:1349-1358. doi: 10.2147/CCID.S519217. eCollection 2025.
BACKGROUND
In the current landscape of aesthetic medicine, the use of hyaluronic acid (HA)-based dermal fillers is increasingly prevalent. Although HA is widely acknowledged for its safety and efficacy the study of its degradability represents a critical aspect in ensuring safety.
METHODS
Rotational rheology was chosen to study the HA-based fillers interaction with hyaluronidase enzyme; this allows to establish a correlation between the viscoelastic parameters of the sample and its degradation.
RESULTS
The obtained results indicate that the products exhibit sensitivity to the enzyme and that the rheological parameters vary depending on the contact time and dosage of administration.
CONCLUSION
Our findings propose a standardized rheological protocol for assessing the degradability of HA-based dermal fillers, offering an alternative to existing methods.
背景
在当前美容医学领域，基于透明质酸（HA）的真皮填充剂的使用越来越普遍。尽管HA因其安全性和有效性而广受认可，但其降解性研究是确保安全性的关键方面。
方法
选择旋转流变学来研究基于HA的填充剂与透明质酸酶的相互作用；这有助于建立样品的粘弹性参数与其降解之间的相关性。
结果
所得结果表明，这些产品对该酶具有敏感性，并且流变学参数会根据接触时间和给药剂量而变化。
结论
我们的研究结果提出了一种用于评估基于HA的真皮填充剂降解性的标准化流变学方案，为现有方法提供了一种替代方案。
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